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   Articles with "sting agonists" as a keyword



Piezo‐STING Agonists Enhance Tumor Penetration and Catalytic‐immunotherapy

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recommendations! Published in 2025 at "Advanced Functional Materials"

DOI: 10.1002/adfm.202419032

Abstract: The cyclic guanosine monophosphate‐adenosine monophosphate synthase (cGAS)‐stimulator of interferon genes (STING) signaling pathway is an important innate immune pathway that has shown remarkable potential in cancer immunotherapy. However, the clinical therapeutic efficacy is limited due… read more here.

Keywords: piezo sting; immunotherapy; sting agonists; tumor ... See more keywords
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Inhibitory Microenvironment Remodeling Enhances STING Activation for Solid Tumor Immunotherapy

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recommendations! Published in 2025 at "Advanced Functional Materials"

DOI: 10.1002/adfm.202421849

Abstract: The immunomodulatory effect of the interferon gene‐stimulating factor (STING) pathway makes it an important target for tumor immunotherapy, which, however, suffers from the easy degradation and deteriorated stimulatory capacity of current STING agonists in the… read more here.

Keywords: tumor immunotherapy; microenvironment; sting agonists; tumor ... See more keywords
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Nanodelivery of STING agonists against cancer and infectious diseases.

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recommendations! Published in 2021 at "Molecular aspects of medicine"

DOI: 10.1016/j.mam.2021.101007

Abstract: Vaccination is a modality that has been widely explored for the treatment of various diseases. To increase the potency of vaccine formulations, immunostimulatory adjuvants have been regularly exploited, and the stimulator of interferon genes (STING)… read more here.

Keywords: infectious diseases; nanodelivery sting; sting agonists; cancer infectious ... See more keywords

Discovery of Selenium-Containing STING Agonists as Orally Available Antitumor Agents.

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recommendations! Published in 2022 at "Journal of medicinal chemistry"

DOI: 10.1021/acs.jmedchem.2c00634

Abstract: Activation of the stimulator of interferon genes (STING) pathway to achieve antitumor response is an attractive approach for cancer immunotherapy. In this study, we report the identification of BSP16 (LF250) as a potent, orally available… read more here.

Keywords: selenium containing; antitumor; sting agonists; orally available ... See more keywords

STING Agonist-Loaded Physalis Mottle Virus-like Particles as a Potent Prophylactic for Metastatic Melanoma.

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recommendations! Published in 2025 at "ACS applied materials & interfaces"

DOI: 10.1021/acsami.5c12494

Abstract: Stimulator of interferon genes (STING) agonists have been presented as a compelling cancer therapeutic for many years yet have been unable to break past clinical trials. To date, the best use cases for STING agonists… read more here.

Keywords: stg; sting agonist; sting agonists; virus ... See more keywords

Sensitizing Tumors to Immune Checkpoint Blockage via STING Agonists Delivered by Tumor-Penetrating Neutrophil Cytopharmaceuticals.

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recommendations! Published in 2023 at "ACS nano"

DOI: 10.1021/acsnano.2c11764

Abstract: Immune checkpoint inhibitors (ICIs) have displayed potential efficacy in triple-negative breast cancer (TNBC) treatment, while only a minority of patients benefit from ICI therapy currently. Although activation of the innate immune stimulator of interferon genes… read more here.

Keywords: immune checkpoint; neutrophil cytopharmaceuticals; sting agonists; tumor ... See more keywords

STING agonists trigger monocyte death via apoptosis, pyroptosis, caspase-8 activation and mitochondrial dysfunction

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recommendations! Published in 2025 at "Cell Death Discovery"

DOI: 10.1038/s41420-025-02786-1

Abstract: The cyclic GMP–AMP synthase–stimulator of interferon genes (cGAS–STING) pathway senses double-stranded DNA in the cytoplasm, triggering the secretion of type I and III interferons and proinflammatory cytokines. However, cGAS–STING pathway activation by STING agonists also… read more here.

Keywords: cgas sting; activation; sting agonists; mitochondrial dysfunction ... See more keywords

Silencing PCSK9 reshapes the spatiotemporal activation of STING for safe and effective cancer immunotherapy.

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recommendations! Published in 2025 at "Nature communications"

DOI: 10.1038/s41467-025-66630-x

Abstract: The cyclic GMP–AMP synthase (cGAS)–stimulator of interferon genes (STING) pathway is a central regulator of innate immunity and a promising target for cancer immunotherapy. However, the clinical translation of STING agonists is limited by suboptimal… read more here.

Keywords: pcsk9; sting agonists; cancer immunotherapy; activation ... See more keywords

Enhancing nano-immunotherapy of cancer through cGAS-STING pathway modulation.

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recommendations! Published in 2025 at "Biomaterials science"

DOI: 10.1039/d4bm01532k

Abstract: Activation of the cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS)-stimulator of interferon genes (STING) pathway plays a critical role in cancer immunotherapy due to the secretion of multiple pro-inflammatory cytokines and chemokines. Numerous cGAS-STING agonists have… read more here.

Keywords: cancer; immunotherapy; sting agonists; sting pathway ... See more keywords

An updated patent review of stimulator of interferon genes agonists (2021 – present)

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recommendations! Published in 2024 at "Expert Opinion on Therapeutic Patents"

DOI: 10.1080/13543776.2024.2365409

Abstract: ABSTRACT Introduction Stimulator of Interferon Genes (STING) is an innate immune sensor. Activation of STING triggers a downstream response that results in the expression of proinflammatory cytokines (TNF-α, IL-1β) via nuclear factor kappa-B (NF-κB) or… read more here.

Keywords: interferon; interferon genes; sting agonists; stimulator interferon ... See more keywords

Anti-tumor immunity by transcriptional synergy between TLR9 and STING activation.

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recommendations! Published in 2022 at "International immunology"

DOI: 10.1093/intimm/dxac012

Abstract: Agonists for TLR9 and STING offer therapeutic applications both as anti-tumor agents and vaccine adjuvants, though their clinical applications are limited; the clinically available TLR9 agonist is a weak IFN inducer and STING agonists induce… read more here.

Keywords: immunity; tlr9 sting; anti tumor; sting agonists ... See more keywords