STING-dependent autophagy suppresses Nosema bombycis infection in silkworms, Bombyx mori.
Sign Up to like & getrecommendations! Published in 2020 at "Developmental and comparative immunology"
DOI: 10.1016/j.dci.2020.103862
Abstract: Nosema bombycis is a unicellular spore-forming obligate parasite, related to fungi, and causes infections in economically important animals and are opportunistic human pathogens. However, the mechanisms of host response to N. bombycis remain unclear. STING… read more here.
Keywords: sting dependent; nosema bombycis; bombyx mori; bmsting 5bp ... See more keywords
STING-dependent paracriny shapes apoptotic priming of breast tumors in response to anti-mitotic treatment
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-019-13689-y
Abstract: A fascinating but uncharacterized action of antimitotic chemotherapy is to collectively prime cancer cells to apoptotic mitochondrial outer membrane permeabilization (MOMP), while impacting only on cycling cell subsets. Here, we show that a proapoptotic secretory… read more here.
Keywords: sting dependent; anti mitotic; breast tumors; cancer cells ... See more keywords
STING-dependent interferon signatures restrict osteoclast differentiation and bone loss in mice.
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2210409120
Abstract: Stimulator of interferon genes (STING) is a key mediator of type-I interferon (IFN-I) signaling in response to a variety of stimuli, but the contribution of STING to homeostatic processes is not fully characterized. Previous studies… read more here.
Keywords: sting dependent; osteoclast differentiation; loss mice; bone loss ... See more keywords
Nanocomplex-based TP53 gene therapy promotes anti-tumor immunity through TP53- and STING-dependent mechanisms
Sign Up to like & getrecommendations! Published in 2018 at "Oncoimmunology"
DOI: 10.1080/2162402x.2017.1404216
Abstract: ABSTRACT Loss or mutation of TP53 has been linked to alterations in anti-tumor immunity as well as dysregulation of cell cycle and apoptosis. We explored immunologic effects and mechanisms following restoration of wild-type human TP53… read more here.
Keywords: sting dependent; tumor immunity; anti tumor; tp53 sting ... See more keywords