A Type I Photosensitizer-Polymersome Boosts Reactive Oxygen Species Generation by Forcing H-Aggregation for Amplifying STING Immunotherapy
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DOI: 10.1021/jacs.4c09831
Abstract: Activation of the innate immune Stimulator of Interferon Genes (STING) pathway potentiates antitumor immunity. However, delivering STING agonists systemically to tumors presents a formidable challenge, and resistance to STING monotherapy has emerged in clinical trials… read more here.
Keywords: type photosensitizer; sting immunotherapy; reactive oxygen;
A Multi-Threshold Micelle Improves Tumor Accumulation and STING Immunotherapy.
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DOI: 10.1021/jacs.4c17082
Abstract: Stimulator of interferon genes (STING) is a critical innate immune protein that potentiates anticancer immunity. An adjuvanted micelle, PC7A, directly binds to STING and coordinates robust immune signaling after local tumor delivery but is not… read more here.
Keywords: multi threshold; improves tumor; pka; sting immunotherapy ... See more keywords