STING and IRF3 in stromal fibroblasts enable sensing of genomic stress in cancer cells to undermine oncolytic viral therapy
Sign Up to like & getrecommendations! Published in 2020 at "Nature Cell Biology"
DOI: 10.1038/s41556-020-0527-7
Abstract: Cancer-associated fibroblasts (CAFs) perform diverse roles and can modulate therapy responses 1 . The inflammatory environment within tumours also influences responses to many therapies, including the efficacy of oncolytic viruses 2 ; however, the role… read more here.
Keywords: therapy; sting irf3; oncolytic viral; cancer cells ... See more keywords
E3 ligase RNF5 inhibits type I interferon response in herpes simplex virus keratitis through the STING/IRF3 signaling pathway
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2022.944101
Abstract: Herpes simplex keratitis (HSK), caused by the herpes simplex virus 1 (HSV-1), is a major blinding disease in developed countries. HSV-1 can remain latent in the host for life and cannot be eradicated. The infection… read more here.
Keywords: keratitis; rnf5; sting irf3; response ... See more keywords