Activation of the cGAS‐STING‐IRF3 Axis by Type I and II Interferons Contributes to Host Defense
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DOI: 10.1002/advs.202308890
Abstract: Interferons (IFNs) activate JAK‐STAT pathways to induce downstream effector genes for host defense against invaded pathogens and tumors. Here both type I (β) and II (γ) IFNs are shown that can activate the transcription factor… read more here.
Keywords: activation; host defense; sting irf3; cgas sting ... See more keywords
STING and IRF3 in stromal fibroblasts enable sensing of genomic stress in cancer cells to undermine oncolytic viral therapy
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DOI: 10.1038/s41556-020-0527-7
Abstract: Cancer-associated fibroblasts (CAFs) perform diverse roles and can modulate therapy responses 1 . The inflammatory environment within tumours also influences responses to many therapies, including the efficacy of oncolytic viruses 2 ; however, the role… read more here.
Keywords: therapy; sting irf3; oncolytic viral; cancer cells ... See more keywords
Exploring endothelial dysfunction in SLE: cGAS-STING-IRF3 pathway activation by dsDNA
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DOI: 10.1177/09612033251386097
Abstract: Background: Systemic lupus erythematosus (SLE) is an autoimmune disease often associated with anti-double stranded DNA (anti-dsDNA) antibodies and endothelial dysfunction, yet the mechanisms linking extracellular DNA to vascular injury remain unclear. Methods: We collected clinical… read more here.
Keywords: dsdna; sting irf3; endothelial dysfunction; cgas sting ... See more keywords
Outer membrane vesicles of Glaesserlla parasuis activate the endosomal cGAS–STING–IRF3 pathway through nucleic acid payload delivery: a biological perspective on host defense protocol optimization
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DOI: 10.1186/s13567-025-01553-5
Abstract: Glaesserlla parasuis (G. parasuis), a Gram-negative pathogen responsible for Glässer's disease, employs outer membrane vesicles (OMVs) as sophisticated nanoscale effectors to modulate host‒pathogen interplay. While bacterial OMVs are recognized as critical mediators of virulence dissemination,… read more here.
Keywords: host; parasuis; sting irf3; parasuis omvs ... See more keywords
E3 ligase RNF5 inhibits type I interferon response in herpes simplex virus keratitis through the STING/IRF3 signaling pathway
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2022.944101
Abstract: Herpes simplex keratitis (HSK), caused by the herpes simplex virus 1 (HSV-1), is a major blinding disease in developed countries. HSV-1 can remain latent in the host for life and cannot be eradicated. The infection… read more here.
Keywords: keratitis; rnf5; sting irf3; response ... See more keywords