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   Articles with "sting mediated" as a keyword



TICAM-1 is dispensable in STING-mediated innate immune responses in myeloid immune cells.

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recommendations! Published in 2018 at "Biochemical and biophysical research communications"

DOI: 10.1016/j.bbrc.2018.04.035

Abstract: Stimulator of interferon genes (STING) is an essential molecule for the production of type I interferon (IFN), and other inflammatory cytokines, in response to cytosolic DNA. STING contributes to host defense against infection and anti-tumor… read more here.

Keywords: innate immune; mediated innate; immune responses; sting mediated ... See more keywords

Supramolecular Cyclic Dinucleotide Nanoparticles for STING-Mediated Cancer Immunotherapy.

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recommendations! Published in 2023 at "ACS nano"

DOI: 10.1021/acsnano.2c12685

Abstract: Activation of stimulator of interferon genes (STING) can reprogram the immunosuppressive tumor microenvironment (TME) by initiating innate and adaptive immunity. As natural STING agonists, clinical translation of cyclic dinucleotides (CDNs) has been challenged by their… read more here.

Keywords: cdg; mediated cancer; cyclic dinucleotide; sting mediated ... See more keywords

Notch signaling protects CD4 T cells from STING-mediated apoptosis during acute systemic inflammation

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recommendations! Published in 2020 at "Science Advances"

DOI: 10.1126/sciadv.abc5447

Abstract: Notch or STING, which is in charge of CD4 T cell fate? Dysregulation of T cell apoptosis contributes to the pathogenesis of acute systemic inflammation–induced immunosuppression, as seen in sepsis and trauma. However, the regulatory… read more here.

Keywords: cd4 cells; sting mediated; apoptosis; notch ... See more keywords

Inhibition of STING-mediated type I IFN signaling by African swine fever virus DP71L

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recommendations! Published in 2025 at "Veterinary Research"

DOI: 10.1186/s13567-025-01474-3

Abstract: African swine fever virus (ASFV) is nucleocytoplasmic large DNA arbovirus and encodes many proteins involved in the interaction with host molecules to evade antiviral immune responses. Especially, evasion strategies of type I interferon (IFN-I)-mediated immune… read more here.

Keywords: african swine; swine fever; dp71l; fever virus ... See more keywords

The Role of STING-Mediated Activation of Dendritic Cells in Cancer Immunotherapy

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recommendations! Published in 2024 at "International Journal of Nanomedicine"

DOI: 10.2147/ijn.s477320

Abstract: Abstract The signaling pathway that comprises cyclic guanosine monophosphate–adenosine monophosphate (cGAMP or GMP-AMP) synthase (cGAS) and Stimulator of Interferon Genes (STING) is emerging as a druggable target for immunotherapy, with tumor-resident dendritic cells (DC) playing… read more here.

Keywords: cancer; role; activation; dendritic cells ... See more keywords

Promising Targets for Cancer Immunotherapy: TLRs, RLRs, and STING-Mediated Innate Immune Pathways

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recommendations! Published in 2017 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms18020404

Abstract: Malignant cancers employ diverse and intricate immune evasion strategies, which lead to inadequately effective responses of many clinical cancer therapies. However, emerging data suggest that activation of the tolerant innate immune system in cancer patients… read more here.

Keywords: rlrs sting; sting mediated; tlrs rlrs; cancer ... See more keywords