TICAM-1 is dispensable in STING-mediated innate immune responses in myeloid immune cells.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.04.035
Abstract: Stimulator of interferon genes (STING) is an essential molecule for the production of type I interferon (IFN), and other inflammatory cytokines, in response to cytosolic DNA. STING contributes to host defense against infection and anti-tumor… read more here.
Keywords: innate immune; mediated innate; immune responses; sting mediated ... See more keywords
Supramolecular Cyclic Dinucleotide Nanoparticles for STING-Mediated Cancer Immunotherapy.
Sign Up to like & getrecommendations! Published in 2023 at "ACS nano"
DOI: 10.1021/acsnano.2c12685
Abstract: Activation of stimulator of interferon genes (STING) can reprogram the immunosuppressive tumor microenvironment (TME) by initiating innate and adaptive immunity. As natural STING agonists, clinical translation of cyclic dinucleotides (CDNs) has been challenged by their… read more here.
Keywords: cdg; mediated cancer; cyclic dinucleotide; sting mediated ... See more keywords
Notch signaling protects CD4 T cells from STING-mediated apoptosis during acute systemic inflammation
Sign Up to like & getrecommendations! Published in 2020 at "Science Advances"
DOI: 10.1126/sciadv.abc5447
Abstract: Notch or STING, which is in charge of CD4 T cell fate? Dysregulation of T cell apoptosis contributes to the pathogenesis of acute systemic inflammation–induced immunosuppression, as seen in sepsis and trauma. However, the regulatory… read more here.
Keywords: cd4 cells; sting mediated; apoptosis; notch ... See more keywords
Promising Targets for Cancer Immunotherapy: TLRs, RLRs, and STING-Mediated Innate Immune Pathways
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms18020404
Abstract: Malignant cancers employ diverse and intricate immune evasion strategies, which lead to inadequately effective responses of many clinical cancer therapies. However, emerging data suggest that activation of the tolerant innate immune system in cancer patients… read more here.
Keywords: rlrs sting; sting mediated; tlrs rlrs; cancer ... See more keywords