Peroxidase‐Like Nanozyme Activates the cGAS‐STING Pathway via ROS‐Induced mtDNA Release for Cancer Immunotherapy
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202401576
Abstract: Although numerous peroxidase (POD)‐like nanozymes have been designed for catalytic therapy of cancer, development of nanozymes with higher therapeutic efficacy and less adverse effects are challengeable. More importantly, the underlying antitumor mechanism remains largely unknown… read more here.
Keywords: cancer; cancer immunotherapy; sting pathway; like nanozyme ... See more keywords
Bimetallic Nanoreactor Activates cGAS‐STING Pathway via mtDNA Release for Cancer Metalloimmunotherapy
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202518279
Abstract: Manganese‐based materials are promising candidates for supporting cyclic dinucleotides for activating the cyclic GMP‐AMP synthase–stimulator of interferon genes (cGAS‐STING) pathway, which is crucial for inducing immune responses against cancer. However, their limited capacity to independently… read more here.
Keywords: cancer; bimetallic nanoreactor; sting pathway; activates cgas ... See more keywords
Targeting STING Activation by Antigen‐Inspired MnO2 Nanovaccines Optimizes Tumor Radiotherapy
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DOI: 10.1002/adhm.202300028
Abstract: Immune checkpoint blockers therapy can improve the radiotherapy‐induced immunosuppression by enhancing interferon secretion, but still suffer from low clinical response rate and potential adverse effects. Mn2+‐mediated activation of interferon gene stimulator (STING) pathway provides an… read more here.
Keywords: sting pathway; radiotherapy; antigen inspired; tumor ... See more keywords
Encapsulation of Platinum Prodrugs into PC7A Polymeric Nanoparticles Combined with Immune Checkpoint Inhibitors for Therapeutically Enhanced Multimodal Chemotherapy and Immunotherapy by Activation of the STING Pathway
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202205241
Abstract: Tumor immunotherapy has emerged as one of the most promising therapeutic methods to treat cancer. Despite its clinical application, the immunosuppressive tumor microenvironment compromises the therapeutic efficiency of this technique. To overcome this limitation, many… read more here.
Keywords: immune checkpoint; immunotherapy; therapeutically enhanced; sting pathway ... See more keywords
Kurarinone Alleviates cGAS‐STING‐Triggered Inflammatory Diseases by Targeting STING
Sign Up to like & getrecommendations! Published in 2025 at "Phytotherapy Research"
DOI: 10.1002/ptr.70023
Abstract: Aberrant activation of the cGAS‐STING pathway has been implicated in the pathogenesis of diverse inflammatory diseases. Kurarinone, a flavonoid compound isolated from Sophorae tonkinensis Radix et Rhizoma, has been reported to exhibit anti‐inflammatory effects and… read more here.
Keywords: activation; sting pathway; kurarinone; inflammatory diseases ... See more keywords
Innovative DCZCMC Platform: Dual Regulation of Cholesterol Dynamics and the cGAS/STING Pathway Activation to Combat Drug Resistance in Tumor Therapy.
Sign Up to like & getrecommendations! Published in 2025 at "Small"
DOI: 10.1002/smll.202509075
Abstract: Chemoresistance remains a daunting challenge in bladder cancer therapy, primarily driven by cholesterol-enriched rigid membranes that impede drug penetration and an immunosuppressive tumor microenvironment (TME) that evades immune surveillance. Herein, a biomimetic nanoplatform (DOX@COD-ZCM@CS, DCZCMC)… read more here.
Keywords: activation; drug; tumor; sting pathway ... See more keywords
Bioactive modulators targeting STING adaptor in cGAS-STING pathway.
Sign Up to like & getrecommendations! Published in 2019 at "Drug discovery today"
DOI: 10.1016/j.drudis.2019.11.007
Abstract: The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING)-pathway triggers innate immune responses by recognizing cytosolic DNA. Recent studies revealed that STING adaptor associates with various diseases, and several modulators targeting STING have been identified… read more here.
Keywords: cgas; sting pathway; targeting sting; sting adaptor ... See more keywords
The STING pathway in response to chlamydial infection.
Sign Up to like & getrecommendations! Published in 2019 at "Microbial pathogenesis"
DOI: 10.1016/j.micpath.2019.103950
Abstract: The past decades have witnessed significant progress in discovery and characterize cytosolic DNA sensing and signaling, especially the understanding of the stimulator of interferon genes (STING). This pathway to foreign nucleic acids enables the initiation… read more here.
Keywords: response chlamydial; infection; pathway response; sting pathway ... See more keywords
The stimulator of interferon genes (STING) pathway is upregulated in striatal astrocytes of patients with multiple system atrophy
Sign Up to like & getrecommendations! Published in 2021 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2021.135972
Abstract: Multiple system atrophy (MSA) is a progressive neurodegenerative disorder characterized by the accumulation of pathogenic phosphorylated α-synuclein in oligodendrocytes. In brains affected by MSA, severe astrogliosis is also observed, but its precise role in MSA… read more here.
Keywords: stimulator interferon; system atrophy; interferon genes; sting pathway ... See more keywords
A Novel Inhibitor of Poly(ADP-Ribose) Polymerase-1 Inhibits Proliferation of a BRCA-Deficient Breast Cancer Cell Line via the DNA Damage-Activated cGAS-STING Pathway.
Sign Up to like & getrecommendations! Published in 2024 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.3c00343
Abstract: Loss-of-function mutations in the Breast Cancer Susceptibility Gene (BRCA1 and BRCA2) are often detected in patients with breast cancer. Poly(ADP-ribose) polymerase-1 (PARP1) plays a key role in the repair of DNA strand breaks, and PARP… read more here.
Keywords: breast cancer; cancer; sting pathway; dna ... See more keywords
Chemical and Biomolecular Strategies for STING Pathway Activation in Cancer Immunotherapy.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical reviews"
DOI: 10.1021/acs.chemrev.1c00750
Abstract: The stimulator of interferon genes (STING) cellular signaling pathway is a promising target for cancer immunotherapy. Activation of the intracellular STING protein triggers the production of a multifaceted array of immunostimulatory molecules, which, in the… read more here.
Keywords: cancer; cancer immunotherapy; sting pathway; activation ... See more keywords