Targeting STING Activation by Antigen‐Inspired MnO2 Nanovaccines Optimizes Tumor Radiotherapy
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202300028
Abstract: Immune checkpoint blockers therapy can improve the radiotherapy‐induced immunosuppression by enhancing interferon secretion, but still suffer from low clinical response rate and potential adverse effects. Mn2+‐mediated activation of interferon gene stimulator (STING) pathway provides an… read more here.
Keywords: sting pathway; radiotherapy; antigen inspired; tumor ... See more keywords
Encapsulation of Platinum Prodrugs into PC7A Polymeric Nanoparticles Combined with Immune Checkpoint Inhibitors for Therapeutically Enhanced Multimodal Chemotherapy and Immunotherapy by Activation of the STING Pathway
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202205241
Abstract: Tumor immunotherapy has emerged as one of the most promising therapeutic methods to treat cancer. Despite its clinical application, the immunosuppressive tumor microenvironment compromises the therapeutic efficiency of this technique. To overcome this limitation, many… read more here.
Keywords: immune checkpoint; immunotherapy; therapeutically enhanced; sting pathway ... See more keywords
Bioactive modulators targeting STING adaptor in cGAS-STING pathway.
Sign Up to like & getrecommendations! Published in 2019 at "Drug discovery today"
DOI: 10.1016/j.drudis.2019.11.007
Abstract: The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING)-pathway triggers innate immune responses by recognizing cytosolic DNA. Recent studies revealed that STING adaptor associates with various diseases, and several modulators targeting STING have been identified… read more here.
Keywords: cgas; sting pathway; targeting sting; sting adaptor ... See more keywords
The STING pathway in response to chlamydial infection.
Sign Up to like & getrecommendations! Published in 2019 at "Microbial pathogenesis"
DOI: 10.1016/j.micpath.2019.103950
Abstract: The past decades have witnessed significant progress in discovery and characterize cytosolic DNA sensing and signaling, especially the understanding of the stimulator of interferon genes (STING). This pathway to foreign nucleic acids enables the initiation… read more here.
Keywords: response chlamydial; infection; pathway response; sting pathway ... See more keywords
The stimulator of interferon genes (STING) pathway is upregulated in striatal astrocytes of patients with multiple system atrophy
Sign Up to like & getrecommendations! Published in 2021 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2021.135972
Abstract: Multiple system atrophy (MSA) is a progressive neurodegenerative disorder characterized by the accumulation of pathogenic phosphorylated α-synuclein in oligodendrocytes. In brains affected by MSA, severe astrogliosis is also observed, but its precise role in MSA… read more here.
Keywords: stimulator interferon; system atrophy; interferon genes; sting pathway ... See more keywords
Chemical and Biomolecular Strategies for STING Pathway Activation in Cancer Immunotherapy.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical reviews"
DOI: 10.1021/acs.chemrev.1c00750
Abstract: The stimulator of interferon genes (STING) cellular signaling pathway is a promising target for cancer immunotherapy. Activation of the intracellular STING protein triggers the production of a multifaceted array of immunostimulatory molecules, which, in the… read more here.
Keywords: cancer; cancer immunotherapy; sting pathway; activation ... See more keywords
Biomineralized MnO2 Nanoplatforms Mediated Delivery of Immune Checkpoint Inhibitors with STING Pathway Activation to Potentiate Cancer Radio-Immunotherapy.
Sign Up to like & getrecommendations! Published in 2023 at "ACS nano"
DOI: 10.1021/acsnano.2c10352
Abstract: Radiotherapy (RT), as one of the main methods in the clinical treatment of various malignant tumors, would induce systemic immunotherapeutic effects by triggering immunogenic cell death (ICD) of cancer cells. However, the antitumor immune responses… read more here.
Keywords: mno2; biomineralized mno2; sting pathway; nanoplatforms mediated ... See more keywords
The cGAS-STING pathway is a therapeutic target in a preclinical model of hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2019 at "Oncogene"
DOI: 10.1038/s41388-019-1108-8
Abstract: Hepatocellular carcinoma (HCC) is the most common primary liver cancer, and the incidence of HCC is increasing. Recently, cancer immunotherapy has emerged as an efficient treatment against some cancers. Here we have used a mouse… read more here.
Keywords: hepatocellular carcinoma; hcc; treatment; cdn ... See more keywords
IFN-γ activates the tumor cell-intrinsic STING pathway through the induction of DNA damage and cytosolic dsDNA formation
Sign Up to like & getrecommendations! Published in 2022 at "Oncoimmunology"
DOI: 10.1080/2162402x.2022.2044103
Abstract: ABSTRACT Stimulator of interferon genes (STING) pathway activation predicts the effectiveness of targeting the PD-1/PD-L1 axis in lung cancer. Active IFN-γ signaling is a common feature in tumors that respond to PD-1/PD-L1 blockade. The connection… read more here.
Keywords: dna damage; sting pathway; ifn; cytosolic dsdna ... See more keywords
Mini-review: The Distinct Roles of STING Signaling in Tumor Immunity-Recent Progress.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of leukocyte biology"
DOI: 10.1093/jleuko/qiad051
Abstract: New strategies targeting stimulator of interferon genes (STING) proteins appear promising for eliciting immunotherapeutic responses. Activation of the STING pathway under the right circumstances can drive dendritic cell maturation, antitumor macrophage differentiation, T cell initiation… read more here.
Keywords: tumor immunity; sting signaling; sting pathway; tumor ... See more keywords
Inhibition of mTOR suppresses IFNα production and the STING pathway in monocytes from systemic lupus erythematosus patients.
Sign Up to like & getrecommendations! Published in 2020 at "Rheumatology"
DOI: 10.1093/rheumatology/keaa060
Abstract: OBJECTIVE Increased IFNα is important in the pathogenesis of SLE. Plasmacytoid dendritic cells are considered the main producer of IFNα upon Toll-like receptor pathway activation. However, which cells produce IFNα following stimulation with cyclic GMP-AMP… read more here.
Keywords: expression; ifn production; ifn; sting pathway ... See more keywords