Phase Separation in cGAS‐STING Signaling: Cytosolic DNA Sensing and Regulatory Functions
Sign Up to like & getrecommendations! Published in 2023 at "ChemBioChem"
DOI: 10.1002/cbic.202300147
Abstract: Phase separation is a crucial biophysical process that governs cellular signaling and function. This process allows biomolecules to separate and form membraneless compartments in response to both extra‐ and intra‐cellular stimuli. Recently, the identification of… read more here.
Keywords: phase separation; separation cgas; cgas sting; sting signaling ... See more keywords
Icaritin ameliorates extracellular microparticles‐induced inflammatory pre‐metastatic niche via modulating the cGAS‐STING signaling
Sign Up to like & getrecommendations! Published in 2022 at "Phytotherapy Research"
DOI: 10.1002/ptr.7433
Abstract: The concept of the inflammatory pre‐metastatic niche (PMN) provides a new and promising direction for the prevention and treatment of metastasis. The excessive activation of the GAS‐STING signaling leads to augmented metastasis by promoting the… read more here.
Keywords: pre metastatic; sting signaling; inflammatory pre; metastatic niche ... See more keywords
The cGAS–STING signaling in cardiovascular and metabolic diseases: Future novel target option for pharmacotherapy
Sign Up to like & getrecommendations! Published in 2021 at "Acta Pharmaceutica Sinica B"
DOI: 10.1016/j.apsb.2021.05.011
Abstract: Abstract The cyclic GMP–AMP synthase (cGAS)–stimulator of interferon genes (STING) signaling exert essential regulatory function in microbial-and onco-immunology through the induction of cytokines, primarily type I interferons. Recently, the aberrant and deranged signaling of the… read more here.
Keywords: cardiovascular metabolic; metabolic diseases; signaling cardiovascular; sting signaling ... See more keywords
Dose-related telomere damage associated with the genetic polymorphisms of cGAS/STING signaling pathway in the workers exposed by PAHs.
Sign Up to like & getrecommendations! Published in 2020 at "Environmental pollution"
DOI: 10.1016/j.envpol.2020.113995
Abstract: Telomeres are located at the end of eukaryotic chromosomes and vulnerable to exogenous chemical compounds. Exposure to coke oven emissions (COEs) leads to a dose-related telomere damage, and such chromosomal damage might trigger the cGAS/STING… read more here.
Keywords: exposure; telomere damage; sting signaling; damage ... See more keywords
Activation of STING signaling accelerates skin wound healing.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of dermatological science"
DOI: 10.1016/j.jdermsci.2019.11.008
Abstract: BACKGROUND The process of repair after skin injury is precisely regulated by a variety of mediators such as cytokines and chemokines. Recent reports demonstrated that cytoplasmic DNA-sensor cyclic GMP-AMP synthase (cGAS) activates the stimulator of… read more here.
Keywords: wound healing; skin wound; cgamp; sting signaling ... See more keywords
Pulmonary inflammatory and fibrogenic response induced by graphitized multi-walled carbon nanotube involved in cGAS-STING signaling pathway.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of hazardous materials"
DOI: 10.1016/j.jhazmat.2021.125984
Abstract: Graphitized multi-walled carbon nanotubes (GMWCNTs) are a new type of nanomaterial. Recently, their production and application in biological medicine have grown rapidly. However, GMWCNTs may cause adverse health effects, including the common occupational disease of… read more here.
Keywords: graphitized multi; fibrosis; walled carbon; sting signaling ... See more keywords
STEEP mediates STING ER exit and activation of signaling
Sign Up to like & getrecommendations! Published in 2020 at "Nature immunology"
DOI: 10.1038/s41590-020-0730-5
Abstract: STING is essential for control of infections and for tumor immunosurveillance, but it can also drive pathological inflammation. STING resides on the endoplasmic reticulum (ER) and traffics following stimulation to the ERGIC/Golgi, where signaling occurs.… read more here.
Keywords: steep mediates; mediates sting; signaling steep; exit ... See more keywords
Modulation of cGAS-STING signaling by PPARα in a mouse model of ischemia-induced retinopathy
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2208934119
Abstract: Significance Ischemic retinopathy is a leading cause of blindness and has unmet medical needs for novel therapeutic strategies. In this work, we found that the cGAS-STING pathway was activated in the retina with ischemia-induced retinopathy,… read more here.
Keywords: ischemia induced; ppar; sting signaling; induced retinopathy ... See more keywords
The balance between gasdermin D and STING signaling shapes the severity of schistosome immunopathology.
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2211047120
Abstract: There is significant disease heterogeneity among mouse strains infected with the helminth Schistosoma mansoni. Here, we uncover a unique balance in two critical innate pathways governing the severity of disease. In the low-pathology setting, parasite… read more here.
Keywords: immunopathology; sting signaling; balance; pathology ... See more keywords
Mini-review: The Distinct Roles of STING Signaling in Tumor Immunity-Recent Progress.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of leukocyte biology"
DOI: 10.1093/jleuko/qiad051
Abstract: New strategies targeting stimulator of interferon genes (STING) proteins appear promising for eliciting immunotherapeutic responses. Activation of the STING pathway under the right circumstances can drive dendritic cell maturation, antitumor macrophage differentiation, T cell initiation… read more here.
Keywords: tumor immunity; sting signaling; sting pathway; tumor ... See more keywords
The crosstalk between the caspase family and the cGAS‒STING signaling pathway.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of molecular cell biology"
DOI: 10.1093/jmcb/mjab071
Abstract: Cytosolic nucleic acid sensors are critical for sensing nucleic acids and initiating innate immunity during microbial infections and/or cell death. Over the last decade, several key studies have characterized the conserved mechanism of cyclic GMP‒AMP… read more here.
Keywords: caspase family; cgas sting; sting signaling; signaling pathway ... See more keywords