Singapore Grouper Iridovirus VP131 Drives Degradation of STING-TBK1 Pathway Proteins and Negatively Regulates Antiviral Innate Immunity
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DOI: 10.1128/jvi.00682-22
Abstract: STING has been identified as a critical factor participating in the innate immune response which recruits and phosphorylates TBK1 and IFN regulatory factor 3 (IRF3) to induce IFN production and defend against viral infection. However,… read more here.
Keywords: sting tbk1; response; infection; ifn ... See more keywords
Leishmania kinetoplast DNA contributes to parasite burden in infected macrophages: Critical role of the cGAS-STING-TBK1 signaling pathway in macrophage parasitemia
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DOI: 10.3389/fimmu.2022.1007070
Abstract: Leishmania parasites harbor a unique network of circular DNA known as kinetoplast DNA (kDNA). The role of kDNA in leishmania infections is poorly understood. Herein, we show that kDNA delivery to the cytosol of Leishmania… read more here.
Keywords: sting tbk1; dna; kinetoplast dna; leishmania ... See more keywords
Inhibitory targeting cGAS-STING-TBK1 axis: Emerging strategies for autoimmune diseases therapy
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DOI: 10.3389/fimmu.2022.954129
Abstract: The cGAS-STING signaling plays an integral role in the host immune response, and the abnormal activation of cGAS-STING is highly related to various autoimmune diseases. Therefore, targeting the cGAS-STING-TBK1 axis has become a promising strategy… read more here.
Keywords: sting tbk1; targeting cgas; autoimmune diseases; cgas sting ... See more keywords
The STING/TBK1/IRF3/IFN type I pathway is defective in cystic fibrosis
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DOI: 10.3389/fimmu.2023.1093212
Abstract: Cystic fibrosis (CF) is a rare autosomal recessive disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. The most common mutation is F508del-CFTR (ΔF) which leads the encoded ion channel towards… read more here.
Keywords: sting tbk1; sting pathway; ifn; tbk1 irf3 ... See more keywords