Application of the compartmental model to the gas–liquid precipitation of CO2-Ca(OH)2 aqueous system in a stirred tank
Sign Up to like & getrecommendations! Published in 2017 at "Aiche Journal"
DOI: 10.1002/aic.15567
Abstract: A compartmental model is formulated to assess the influence of fluid dynamics on the gas–liquid precipitation of CO2(g)-Ca(OH)2(aq) system in a stirred tank reactor. The model combines the description of the flow field with several… read more here.
Keywords: gas liquid; precipitation; compartmental model; gas ... See more keywords
Polymersome formation mechanism and formation rate in stirred‐tank reactors
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Applied Polymer Science"
DOI: 10.1002/app.46077
Abstract: Uniform polymersomes (polymer vesicles) made of poly(2-methyloxazoline)15-b-poly(dimethylsiloxane)68-b-poly(2-methyloxazoline)15 (PMOXA15–PDMS68–PMOXA15) can be formed in miniaturized-stirred tank reactors by the aid of a recently published process. In this study, the occurring self-assembly mechanism was elucidated by using transmission… read more here.
Keywords: stirred tank; formation rate; tank reactors; formation ... See more keywords
Identification of critical process parameters for expansion of clinical grade human Wharton's jelly‐derived mesenchymal stromal cells in stirred‐tank bioreactors
Sign Up to like & getrecommendations! Published in 2024 at "Biotechnology Journal"
DOI: 10.1002/biot.202300381
Abstract: Cell therapies based on multipotent mesenchymal stromal cells (MSCs) are traditionally produced using 2D culture systems and platelet lysate‐ or serum‐containing media (SCM). Although cost‐effective for single‐dose autologous treatments, this approach is not suitable for… read more here.
Keywords: tank bioreactors; mesenchymal stromal; stromal cells; critical process ... See more keywords
Enhanced bioprocess control to advance the manufacture of mesenchymal stromal cell-derived extracellular vesicles in stirred-tank bioreactors.
Sign Up to like & getrecommendations! Published in 2023 at "Biotechnology and bioengineering"
DOI: 10.1002/bit.28378
Abstract: Extracellular vesicles (EVs) derived from mesenchymal stromal cells (MSCs) act as signalling mediators of cellular responses. However, despite representing a promising alternative to cell-based therapies, clinical translation of EVs is currently limited by their lack… read more here.
Keywords: cell; extracellular vesicles; mesenchymal stromal; manufacture ... See more keywords
The transient expression of CHIKV VLP in large stirred tank bioreactors
Sign Up to like & getrecommendations! Published in 2019 at "Cytotechnology"
DOI: 10.1007/s10616-019-00346-x
Abstract: Transient gene expression (TGE) bioprocesses have been difficult to scale up in large stirred tank bioreactors with volumes of more than 1.5 L. Low production levels are often observed, but the causes have not been… read more here.
Keywords: stirred tank; transient expression; tank bioreactors; large stirred ... See more keywords
Limits to biomass productivity during fed-batch cultivation of Laminaria saccharina female gametophyte cells in a stirred-tank photobioreactor
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Applied Phycology"
DOI: 10.1007/s10811-020-02328-5
Abstract: This study compared the growth of Laminaria saccharina female gametophyte filamentous cell suspension cultures in a stirred-tank photobioreactor under batch and fed-batch nutrient addition modes over a 48-day cultivation period. Cultures were grown on GP2… read more here.
Keywords: batch cultivation; productivity; cultivation; stirred tank ... See more keywords
Process development for expansion of human mesenchymal stromal cells in a 50 L single-use stirred tank bioreactor
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical Engineering Journal"
DOI: 10.1016/j.bej.2016.11.020
Abstract: Abstract The application of cell-based therapeutics requires development of refined and scalable culture processes. Stirred tank bioreactors facilitate growth of human mesenchymal stromal cells (hMSC) while meeting these needs. A process for expansion of hMSCs… read more here.
Keywords: human mesenchymal; mesenchymal stromal; expansion; bioreactor ... See more keywords
Aeration costs in stirred-tank and bubble column bioreactors
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical Engineering Journal"
DOI: 10.1016/j.bej.2017.08.006
Abstract: Abstract To overcome knowledge gaps in the economics of large-scale aeration for production of commodity products, Aspen Plus is used to simulate steady-state oxygen delivery in both stirred-tank and bubble column bioreactors, using published engineering… read more here.
Keywords: tank bubble; aeration; stirred tank; oxygen delivery ... See more keywords
Performance of fungal microparticle-enhanced cultivations in stirred tank bioreactors depends on species and number of process stages
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical Engineering Journal"
DOI: 10.1016/j.bej.2020.107696
Abstract: Abstract Species-dependent mechanisms of morphological development affect filamentous fungi cultivations. In order to influence fungal morphology microparticle-enhanced cultivations (MPEC) were used towards four species exhibiting various mechanisms of morphology formation: a spore agglomerative Aspergillus terreus,… read more here.
Keywords: hyphae agglomerative; microparticle enhanced; tank bioreactors; enhanced cultivations ... See more keywords
Serial completely stirred tank reactors for improving biogas production and substance degradation during anaerobic digestion of corn stover.
Sign Up to like & getrecommendations! Published in 2017 at "Bioresource technology"
DOI: 10.1016/j.biortech.2017.03.058
Abstract: Several completely stirred tank reactors (CSTR) connected in series for anaerobic digestion of corn stover were investigated in laboratory scale. Serial anaerobic digestion systems operated at a total HRT of 40days, and distribution of HRT… read more here.
Keywords: production; digestion; stirred tank; tank reactors ... See more keywords
CFD analysis of the flow dynamics of microorganisms in dilute cultures in stirred tank photobioreactors
Sign Up to like & getrecommendations! Published in 2018 at "Bioresource Technology Reports"
DOI: 10.1016/j.biteb.2018.07.017
Abstract: Abstract The objective of the present work is to investigate the influence of the key factors such as the impeller speed in revolutions per minute and frequency of crossover of the particles between the light… read more here.
Keywords: dynamics microorganisms; stirred tank; flow dynamics; microorganisms dilute ... See more keywords