STK11 rs2075604 Polymorphism Is Associated with Metformin Efficacy in Chinese Type 2 Diabetes Mellitus
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Endocrinology"
DOI: 10.1155/2017/3402808
Abstract: Metformin is a classical oral antidiabetic drug, often recommended to be the first-choice treatment of type 2 diabetes mellitus (T2DM). Based on the previous research on STK11 and diabetes, we aimed to investigate the distributive… read more here.
Keywords: stk11 rs2075604; stk11; metformin efficacy; polymorphism ... See more keywords
Abstract 2137: Clinical utility of circulating tumor DNA in patients with advanced KRAS G12C-mutated NSCLC treated with sotorasib
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-2137
Abstract: Introduction: The CodeBreaK 200 trial showed that in patients (pts) with advanced KRAS G12C mutated (KRAS+) NSCLC sotorasib, a KRAS G12C-specific inhibitor, is superior to docetaxel for progression free survival (PFS) (HR 0.66) with a… read more here.
Keywords: kras g12c; ctdna; keap1; stk11 ... See more keywords
Abstract 3245: AXL as a therapeutic target in STK11 mutant NSCLC
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-3245
Abstract: STK11 (LKB1) is a tumor suppressor, and loss-of-function mutations contribute to tumorigenesis. Mutations in the STK11 gene (STK11m) are present in ~ 20% of NSCLCs and are associated with poor response to chemotherapy and immune… read more here.
Keywords: bemcentinib; stk11; tumor; axl ... See more keywords
Abstract 5944: Relief of chromosomal instability-induced cGAS-STING signaling sensitizes STK11-mutant non-small cell lung cancer to immune checkpoint blockade
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-5944
Abstract: Non-small cell lung cancers (NSCLCs) harboring deletions or inactivating mutations in STK11 (encoding LKB1) are associated with treatment-resistance, including to immune checkpoint blockade, and poor survival, yet the underlying mechanisms are poorly understood. Here, we… read more here.
Keywords: cell; non small; stk11; stk11 mutant ... See more keywords
Ovarian Mucinous Tumor Presenting Atypical Lobular Endocervical Glandular Hyperplasia-Like Appearance in a Patient With Germline STK11 p.F354L Variant: A Case Report.
Sign Up to like & getrecommendations! Published in 2023 at "International journal of surgical pathology"
DOI: 10.1177/10668969231177256
Abstract: Peutz-Jeghers syndrome (PJS) is associated with female genital lesions, such as cervical gastric-type adenocarcinoma and lobular endocervical glandular hyperplasia (LEGH). However, ovarian mucinous borderline tumors (OMBT) with atypical LEGH-like histology have not been described. The… read more here.
Keywords: stk11 f354l; germline stk11; stk11; f354l variant ... See more keywords
Early screening the small bowel is key to protect Peutz-Jeghers syndrome patients from surgery: a novel mutation c.243delG in STK11 gene
Sign Up to like & getrecommendations! Published in 2019 at "BMC Gastroenterology"
DOI: 10.1186/s12876-019-0987-z
Abstract: BackgroundPeutz-Jeghers syndrome (PJS) is a Mendelian disease, whose causative gene is STK11, mainly characterized by gastrointestinal polyposis and increased cancer risk. Clinical observation reveals intussusception in childhood are more frequent and severe than in adults,… read more here.
Keywords: small bowel; stk11; jeghers syndrome; gene ... See more keywords
STK11/TP53 co-mutated non-small cell lung cancer (NSCLC) to display a unique tumor microenvironment (TME) and metabolic profile.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2021.39.15_suppl.9087
Abstract: 9087 Background: Recent data suggest inferior responses to immune checkpoint inhibitors (ICIs) in STK11-mt NSCLC. TP53 is a critical tumor suppressor gene regulating DNA repair by arresting cells in the G1 phase in response to… read more here.
Keywords: stk11 nsclc; stk11; cell; tumor ... See more keywords
Association Between the Efficacy of Pembrolizumab and Low STK11/LKB1 Expression in High-PD-L1-expressing Non-small-cell Lung Cancer
Sign Up to like & getrecommendations! Published in 2020 at "In Vivo"
DOI: 10.21873/invivo.12131
Abstract: Background/Aim: STK11/LKB1 mutation has been suggested as a poorly responding candidate biomarker of the anti-programmed cell death-1 (PD-1) antibody; however, the association between STK11/LKB1 expression and the effects of anti-PD-1 antibodies is uncertain. The aim… read more here.
Keywords: stk11; low stk11; lkb1 expression; stk11 lkb1 ... See more keywords
Construction of an STK11 Mutation and Immune-Related Prognostic Prediction Model in Lung Adenocarcinoma
Sign Up to like & getrecommendations! Published in 2023 at "Iranian Journal of Biotechnology"
DOI: 10.30498/ijb.2022.307202.3168
Abstract: Background: STK11 mutation in LUAD affects immune cell infiltration in tumor tissue, and is associated with tumor prognosis. Objective: This study aimed to construct a STK11 mutation and immune-related LUAD prognostic model. Materials and Methods:… read more here.
Keywords: stk11 mutation; luad; stk11; immune related ... See more keywords
Metformin Combining PD-1 Inhibitor Enhanced Anti-Tumor Efficacy in STK11 Mutant Lung Cancer Through AXIN-1-Dependent Inhibition of STING Ubiquitination
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2022.780200
Abstract: Background: Non-small-cell lung cancer (NSCLC) with STK11 mutation showed primary resistance to immune checkpoint inhibitors (ICIs). The glucose-lowering drug metformin exerted anti-cancer effect and enhanced efficacy of chemotherapy in NSCLC with KRAS/STK11 co-mutation, yet it… read more here.
Keywords: metformin; efficacy stk11; stk11; axin ... See more keywords