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   Articles with "stk11" as a keyword



STK11 rs2075604 Polymorphism Is Associated with Metformin Efficacy in Chinese Type 2 Diabetes Mellitus

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recommendations! Published in 2017 at "International Journal of Endocrinology"

DOI: 10.1155/2017/3402808

Abstract: Metformin is a classical oral antidiabetic drug, often recommended to be the first-choice treatment of type 2 diabetes mellitus (T2DM). Based on the previous research on STK11 and diabetes, we aimed to investigate the distributive… read more here.

Keywords: stk11 rs2075604; stk11; metformin efficacy; polymorphism ... See more keywords

Abstract C105: Gain of function cDNA screen identifies SIK3 activation as a therapeutic strategy for STK11 mutant cancer

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recommendations! Published in 2025 at "Molecular Cancer Therapeutics"

DOI: 10.1158/1535-7163.targ-25-c105

Abstract: STK11 (also known as LKB1) is a master serine/threonine kinase that regulates a diverse array of cellular functions via phosphorylation of downstream kinases. STK11 is frequently mutated in human cancers, and we hypothesized that reactivation… read more here.

Keywords: cancer; gain function; cdna; activation ... See more keywords

Abstract 2137: Clinical utility of circulating tumor DNA in patients with advanced KRAS G12C-mutated NSCLC treated with sotorasib

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recommendations! Published in 2023 at "Cancer Research"

DOI: 10.1158/1538-7445.am2023-2137

Abstract: Introduction: The CodeBreaK 200 trial showed that in patients (pts) with advanced KRAS G12C mutated (KRAS+) NSCLC sotorasib, a KRAS G12C-specific inhibitor, is superior to docetaxel for progression free survival (PFS) (HR 0.66) with a… read more here.

Keywords: kras g12c; ctdna; keap1; stk11 ... See more keywords
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Abstract 3245: AXL as a therapeutic target in STK11 mutant NSCLC

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recommendations! Published in 2023 at "Cancer Research"

DOI: 10.1158/1538-7445.am2023-3245

Abstract: STK11 (LKB1) is a tumor suppressor, and loss-of-function mutations contribute to tumorigenesis. Mutations in the STK11 gene (STK11m) are present in ~ 20% of NSCLCs and are associated with poor response to chemotherapy and immune… read more here.

Keywords: bemcentinib; stk11; tumor; axl ... See more keywords

Abstract 5944: Relief of chromosomal instability-induced cGAS-STING signaling sensitizes STK11-mutant non-small cell lung cancer to immune checkpoint blockade

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recommendations! Published in 2023 at "Cancer Research"

DOI: 10.1158/1538-7445.am2023-5944

Abstract: Non-small cell lung cancers (NSCLCs) harboring deletions or inactivating mutations in STK11 (encoding LKB1) are associated with treatment-resistance, including to immune checkpoint blockade, and poor survival, yet the underlying mechanisms are poorly understood. Here, we… read more here.

Keywords: cell; non small; stk11; stk11 mutant ... See more keywords

Abstract 3026: STK11 negatively regulates NFKB signaling in KRAS-driven lung adenocarcinoma

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recommendations! Published in 2024 at "Cancer Research"

DOI: 10.1158/1538-7445.am2024-3026

Abstract: In the US, more people die each year from lung cancer than breast, colorectal, and prostate cancers combined. Despite advances in lung cancer detection and treatment, the overall prognosis for patients remains poor. Patients whose… read more here.

Keywords: cancer; resistance; therapy; stk11 loss ... See more keywords

Abstract 5088: Evaluating TNF-receptor associated factor 2 (TRAF2) as a targetable driver of immune resistance in LKB1 deficient non-small cell lung cancer

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recommendations! Published in 2024 at "Cancer Research"

DOI: 10.1158/1538-7445.am2024-5088

Abstract: STK11 is a serine-threonine kinase and tumor suppressor lost in about 25% of NSCLC. It potently regulates a network of downstream effector kinases in the AMPK family, thereby exerting major effects on cell signaling, metabolic… read more here.

Keywords: cancer; resistance; traf2; ciap1 ... See more keywords

Abstract 5143: Using a multipronged approach to characterize C-terminal domain polybasic motif STK11 variants

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recommendations! Published in 2025 at "Cancer Research"

DOI: 10.1158/1538-7445.am2025-5143

Abstract: KRAS-driven lung adenocarcinomas (LUADs) with concurrent STK11 loss of function (LoF) mutations are associated with aggressive tumors with increased risk of metastasis and lower overall and progression free survival. In LUAD, STK11 LoF impacts many… read more here.

Keywords: terminal domain; kinase; polybasic motif; stk11 ... See more keywords

Abstract 5391: The hexosamine biosynthetic pathway promotes metastatic potential upon glutamine deprivation in STK11 null KRAS-driven lung adenocarcinoma

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recommendations! Published in 2025 at "Cancer Research"

DOI: 10.1158/1538-7445.am2025-5391

Abstract: Lung cancer is the leading cause of cancer-related deaths worldwide, with ∼15, 000 annual US cases presenting with an aggressive lung adenocarcinoma (LUAD) driven by co-mutations in KRAS and STK11 (KS). Loss of STK11 function… read more here.

Keywords: metastatic potential; glutamine deprivation; stk11 cells; stk11 ... See more keywords
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Ovarian Mucinous Tumor Presenting Atypical Lobular Endocervical Glandular Hyperplasia-Like Appearance in a Patient With Germline STK11 p.F354L Variant: A Case Report.

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recommendations! Published in 2023 at "International journal of surgical pathology"

DOI: 10.1177/10668969231177256

Abstract: Peutz-Jeghers syndrome (PJS) is associated with female genital lesions, such as cervical gastric-type adenocarcinoma and lobular endocervical glandular hyperplasia (LEGH). However, ovarian mucinous borderline tumors (OMBT) with atypical LEGH-like histology have not been described. The… read more here.

Keywords: stk11 f354l; germline stk11; stk11; f354l variant ... See more keywords

Early screening the small bowel is key to protect Peutz-Jeghers syndrome patients from surgery: a novel mutation c.243delG in STK11 gene

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recommendations! Published in 2019 at "BMC Gastroenterology"

DOI: 10.1186/s12876-019-0987-z

Abstract: BackgroundPeutz-Jeghers syndrome (PJS) is a Mendelian disease, whose causative gene is STK11, mainly characterized by gastrointestinal polyposis and increased cancer risk. Clinical observation reveals intussusception in childhood are more frequent and severe than in adults,… read more here.

Keywords: small bowel; stk11; jeghers syndrome; gene ... See more keywords