Abstract CT084: Relationship betweenSTK11andKEAP1mutational status and efficacy in KEYNOTE-042: pembrolizumab monotherapy versus platinum-based chemotherapy as first-line therapy for PD-L1-positive advanced NSCLC
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DOI: 10.1158/1538-7445.am2020-ct084
Abstract: Background:STK11 (also known as LKB1) and KEAP1 mutations have been associated with chemoresistance and poor outcomes and shown to be more frequent in PD-L1-negative tumors with high tumor mutational burden (TMB). We performed an exploratory… read more here.
Keywords: keap1 status; efficacy; keynote 042; stk11 keap1 ... See more keywords
Abstract LB014: Targeting Stearoyl-coA desaturase (SCD) as a therapeutic strategy in STK11/KEAP1 co-mutant non-small cell lung cancer
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DOI: 10.1158/1538-7445.am2023-lb014
Abstract: Introduction: Non-small cell lung cancer (NSCLC) is a highly prevalent subtype of lung cancer. Recent findings in the field have improved the clinical outcomes for only a subset of patients who are responsive to immunotherapy… read more here.
Keywords: cell; keap1; keap1 mutant; stk11 keap1 ... See more keywords
Association of a STK11/KEAP1-mutation gene expression signature in lung adenocarcinoma with immune desertion in squamous cell carcinomas and mediation by NFE2L2 deregulation.
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DOI: 10.1200/jco.2020.38.15_suppl.3082
Abstract: 3082Background: KEAP1 and STK11 mutations are associated with resistance to immune checkpoint inhibition (ICI) in non-small cell lung cancer (NSCLC). Mechanisms are currently unknown. Methods: We e... read more here.
Keywords: mutation gene; association stk11; stk11 keap1; cell ... See more keywords
Concurrent Mutations in STK11 and KEAP1 Cause Treatment Resistance in KRAS Wild-type Non-small-cell Lung Cancer.
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DOI: 10.2169/internalmedicine.1110-22
Abstract: We herein report a patient with KRAS wild-type non-small-cell lung cancer (NSCLC) with concurrent STK11 and KEAP1 mutations. A 53-year-old man visited a local doctor with a complaint of left shoulder swelling and pain. He… read more here.
Keywords: kras wild; stk11 keap1; resistance; wild type ... See more keywords