A Chemical Probe for Dark Kinase STK17B Derives Its Potency and High Selectivity through a Unique P-Loop Conformation.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.0c01174
Abstract: STK17B is a member of the death-associated protein kinase family and has been genetically linked to the development of diverse diseases. However, the role of STK17B in normal and disease pathology is poorly defined. Here,… read more here.
Keywords: loop conformation; stk17b; unique loop; dark kinase ... See more keywords
Prognostic and immune-related value of STK17B in skin cutaneous melanoma
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DOI: 10.1371/journal.pone.0263311
Abstract: Skin cutaneous melanoma (SKCM) is a common cancer of which mortality is increasing continuously. Our study conducted a series of analyses on the clinical significance of Serine/threonine kinase 17B (STK17B) in SKCM to provide a… read more here.
Keywords: melanoma; expression; skin cutaneous; immune ... See more keywords