Sublethal β-lactam antibiotics induce PhpP phosphatase expression and StkP kinase phosphorylation in PBP-independent β-lactam antibiotic resistance of Streptococcus pneumoniae.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.07.148
Abstract: StkP and PhpP of Streptococcus pneumoniae have been confirmed to compose a signaling couple, in which the former is a serine/threonine (Ser/Thr) kinase while the latter was annotated as a phosphotase. StkP has been reported… read more here.
Keywords: expression stkp; pbp independent; phpp; stkp ... See more keywords
PASTA repeats of the protein kinase StkP interconnect cell constriction and separation of Streptococcus pneumoniae
Sign Up to like & getrecommendations! Published in 2017 at "Nature Microbiology"
DOI: 10.1038/s41564-017-0069-3
Abstract: Eukaryotic-like serine/threonine kinases (eSTKs) with extracellular PASTA repeats are key membrane regulators of bacterial cell division. How PASTA repeats govern eSTK activation and function remains elusive. Using evolution- and structural-guided approaches combined with cell imaging, we… read more here.
Keywords: pasta; pasta repeats; stkp; streptococcus pneumoniae ... See more keywords
StkP- and PhpP-Mediated Posttranslational Modifications Modulate the S. pneumoniae Metabolism, Polysaccharide Capsule, and Virulence
Sign Up to like & getrecommendations! Published in 2023 at "Infection and Immunity"
DOI: 10.1128/iai.00296-22
Abstract: Pneumococcal Ser/Thr kinase (StkP) and its cognate phosphatase (PhpP) play a crucial role in bacterial cytokinesis. However, their individual and reciprocal metabolic and virulence regulation-related functions have yet to be adequately investigated in encapsulated pneumococci.… read more here.
Keywords: virulence; stkp; phpp; d39 ... See more keywords