Drug resistance dependent on allostery: A P-loop rigor Eg5 mutant exhibits resistance to allosteric inhibition by STLC
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DOI: 10.3389/fonc.2022.965455
Abstract: The mitotic kinesin Eg5 has emerged as a potential anti-mitotic target for the purposes of cancer chemotherapy. Whether clinical resistance to these inhibitors can arise is unclear. We exploited HCT116 cancer cell line to select… read more here.
Keywords: loop; resistant clones; resistance; stlc ... See more keywords