Challenges of analysing stochastic gene expression in bacteria using single-cell time-lapse experiments
Sign Up to like & getrecommendations! Published in 2021 at "Essays in Biochemistry"
DOI: 10.1042/ebc20200015
Abstract: Abstract Stochastic gene expression causes phenotypic heterogeneity in a population of genetically identical bacterial cells. Such non-genetic heterogeneity can have important consequences for the population fitness, and therefore cells implement regulation strategies to either suppress… read more here.
Keywords: gene; gene expression; time lapse; stochastic gene ... See more keywords
Inference and uncertainty quantification of stochastic gene expression via synthetic models
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the Royal Society Interface"
DOI: 10.1101/2022.01.25.477666
Abstract: Estimating uncertainty in model predictions is a central task in quantitative biology. Biological models at the single-cell level are intrinsically stochastic and nonlinear, creating formidable challenges for their statistical estimation which inevitably has to rely… read more here.
Keywords: uncertainty quantification; uncertainty; gene expression; stochastic gene ... See more keywords
Exact distributions for stochastic gene expression models with arbitrary promoter architecture and translational bursting.
Sign Up to like & getrecommendations! Published in 2022 at "Physical review. E"
DOI: 10.1103/physreve.105.014405
Abstract: Gene expression in individual cells is inherently variable and sporadic, leading to cell-to-cell variability in mRNA and protein levels. Recent single-cell and single-molecule experiments indicate that promoter architecture and translational bursting play significant roles in… read more here.
Keywords: stochastic gene; promoter architecture; gene expression; expression ... See more keywords
Stochastic gene expression: bacterial elites in chemotaxis
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Systems Biology"
DOI: 10.15252/msb.20167458
Abstract: Even in the absence of genetic or environmental differences, cells differ from each other in their molecular make‐up. The consequences of these phenotypic differences are often not well understood. New work by Waite et al… read more here.
Keywords: bacterial elites; gene expression; stochastic gene; expression bacterial ... See more keywords