M51R and Delta-M51 matrix protein of the vesicular stomatitis virus induce apoptosis in colorectal cancer cells
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DOI: 10.1007/s11033-019-04799-3
Abstract: Colorectal cancer (CRC) is the third most common cancer in both men and women. Oncolytic viral-based therapy methods seem to be promising for CRC treatment. Vesicular stomatitis virus (VSV) is considered as a potent candidate… read more here.
Keywords: protein; m51; colorectal cancer; vesicular stomatitis ... See more keywords
Mechanisms of anti-vesicular stomatitis virus activity of deazaneplanocin and its 3-brominated analogues.
Sign Up to like & getrecommendations! Published in 2021 at "Antiviral research"
DOI: 10.1016/j.antiviral.2021.105088
Abstract: 3-deazaneplanocin A (DzNep) and its 3-brominated analogues inhibit replication of several RNA viruses. This antiviral activity is attributed to inhibition of S-adenosyl homocysteine hydrolase (SAHase) and consequently inhibition of viral methyltransferases, impairing translation of viral… read more here.
Keywords: cl123; vesicular stomatitis; stomatitis virus; activity ... See more keywords
Structure of the Vesicular Stomatitis Virus L Protein in Complex with Its Phosphoprotein Cofactor
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DOI: 10.1016/j.celrep.2019.12.024
Abstract: SUMMARY The large (L) proteins of non-segmented, negativestrand RNA viruses are multifunctional enzymes that produce capped, methylated, and polyadenylated mRNA and replicate the viral genome. A phosphoprotein (P), required for efficient RNA-dependent RNA polymerization from… read more here.
Keywords: structure vesicular; stomatitis virus; vesicular stomatitis; phosphoprotein ... See more keywords
Ebola epidemic in war-torn Democratic Republic of Congo, 2018: Acceptability and patient satisfaction of the recombinant Vesicular Stomatitis Virus - Zaire Ebolavirus Vaccine.
Sign Up to like & getrecommendations! Published in 2019 at "Vaccine"
DOI: 10.1016/j.vaccine.2019.03.004
Abstract: BACKGROUND The current Ebola outbreak in Eastern Democratic Republic of the Congo (DRC) is the second largest in history and the first in which the recombinant Vesicular Stomatitis Virus - Zaire Ebolavirus (rVSV-ZEBOV) vaccine has… read more here.
Keywords: democratic republic; republic congo; recombinant vesicular; vesicular stomatitis ... See more keywords
Vesicular stomatitis virus nucleocapsids diffuse through cytoplasm by hopping from trap to trap in random directions
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DOI: 10.1038/s41598-020-66942-6
Abstract: Within 2–6 hours after infection by vesicular stomatitis virus (VSV), newly assembled VSV particles are released from the surface of infected cells. In that time, viral ribonucleoprotein (RNP) particles (nucleocapsids) travel from their initial sites of… read more here.
Keywords: stomatitis virus; rnp particles; vesicular stomatitis; trap ... See more keywords
Antifibrotic therapy augments the antitumor effects of vesicular stomatitis virus via reprogramming tumor microenvironment.
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DOI: 10.1089/hum.2021.048
Abstract: Solid tumors are characterized by abundant extracellular matrix originating from cancer-associated fibroblasts (CAFs). High collagen content can trigger the collapse of vascular system in the tumor and form physical barrier that eventually impedes the penetration… read more here.
Keywords: vesicular stomatitis; therapy; stomatitis virus; tumor microenvironment ... See more keywords
A Methyltransferase-Defective Vesicular Stomatitis Virus-Based SARS-CoV-2 Vaccine Candidate Provides Complete Protection against SARS-CoV-2 Infection in Hamsters
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DOI: 10.1128/jvi.00592-21
Abstract: Viral mRNA cap methyltransferase (MTase) is essential for mRNA stability, protein translation, and innate immune evasion. Thus, viral mRNA cap MTase activity is a novel target for development of live attenuated or live vectored vaccine… read more here.
Keywords: vesicular stomatitis; stomatitis virus; sars cov; vaccine candidates ... See more keywords
Rapid Protection from COVID-19 in Nonhuman Primates Vaccinated Intramuscularly but Not Intranasally with a Single Dose of a Vesicular Stomatitis Virus-Based Vaccine
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DOI: 10.1128/mbio.03379-21
Abstract: The vesicular stomatitis virus (VSV) vaccine platform rose to fame in 2019, when a VSV-based Ebola virus (EBOV) vaccine was approved by the European Medicines Agency and the U.S. Food and Drug Administration for human… read more here.
Keywords: vsv; single dose; stomatitis virus; vesicular stomatitis ... See more keywords
Polymer Vector Loading Vesicular Stomatitis Virus Matrix Protein Gene for Colon Cancer Therapy.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of biomedical nanotechnology"
DOI: 10.1166/jbn.2020.2987
Abstract: Gene therapy has been widely studied in colon cancer treatment. However, effective delivery of genes is a limitation for clinical applications. In the research, DOATP/mPEG-PLA-mPEG (DPLP) nanoparticles carrying the vesicular stomatitis virus matrix protein plasmid… read more here.
Keywords: colon; vesicular stomatitis; colon cancer; therapy ... See more keywords
Development of an Oncolytic Recombinant Vesicular Stomatitis Virus Encoding a Tumor-suppressor MicroRNA
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DOI: 10.21873/anticanres.14652
Abstract: Background: Attempts have been made to enhance systemic therapy for osteosarcoma. In our previous study, the systemic administration of a vesicular stomatitis virus (VSV) improved the survival rates of mice with osteosarcoma but did not… read more here.
Keywords: tumor suppressor; stomatitis virus; vesicular stomatitis; tumor ... See more keywords
Evaluating Temperature Sensitivity of Vesicular Stomatitis Virus–Based Vaccines
Sign Up to like & getrecommendations! Published in 2019 at "Emerging Infectious Diseases"
DOI: 10.3201/eid2508.190281
Abstract: Use of the vesicular stomatitis virus (VSV)–based Ebola virus vaccine during outbreaks and the potential use of a similar VSV-based Lassa virus vaccine has raised questions about the vaccines’ stability should the cold chain fail.… read more here.
Keywords: temperature sensitivity; vesicular stomatitis; evaluating temperature; stomatitis virus ... See more keywords