Reassigning stop codons via translation termination: How a few eukaryotes broke the dogma
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DOI: 10.1002/bies.201600213
Abstract: The genetic code determines how amino acids are encoded within mRNA. It is universal among the vast majority of organisms, although several exceptions are known. Variant genetic codes are found in ciliates, mitochondria, and numerous… read more here.
Keywords: codons via; genetic codes; stop codons; reassigning stop ... See more keywords
In vitro suppression of two different stop codons
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DOI: 10.1002/bit.26226
Abstract: Proteins play a crucial role in all living organisms, with the 20 natural amino acids as their building blocks. Unnatural amino acids are synthetic derivatives of these natural building blocks. These amino acids have unique… read more here.
Keywords: amino acids; different stop; two different; unnatural amino ... See more keywords
Stop codons in the hepatitis B surface proteins are enriched during antiviral therapy and are associated with host cell apoptosis.
Sign Up to like & getrecommendations! Published in 2017 at "Virology"
DOI: 10.1016/j.virol.2016.11.007
Abstract: Premature stop codons in the hepatitis B virus (HBV) surface protein can be associated with nucleos(t)ide analogue resistance due to overlap of the HBV surface and polymerase genes. The aim of this study was to… read more here.
Keywords: codons hepatitis; apoptosis; surface; surface stop ... See more keywords
Monitoring translation in all reading frames downstream of weak stop codons provides mechanistic insights into the impact of nucleotide and cellular contexts
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DOI: 10.1093/nar/gkac1180
Abstract: Abstract A stop codon entering the ribosome A-site is normally decoded by release factors that induce release of the polypeptide. Certain factors influence the efficiency of the termination which is in competition with elongation in… read more here.
Keywords: stop codons; reading frames; frames downstream; termination ... See more keywords
Effect of Ataluren on dystrophin mutations
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DOI: 10.1111/jcmm.15319
Abstract: Duchenne muscular dystrophy is a severe muscle wasting disease caused by mutations in the dystrophin gene (dmd). Ataluren has been approved by the European Medicines Agency for treatment of Duchenne muscular dystrophy. Ataluren has been… read more here.
Keywords: effect; effect ataluren; premature stop; stop codons ... See more keywords
Mechanisms that ensure speed and fidelity in eukaryotic translation termination
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DOI: 10.1126/science.abi7801
Abstract: How translation stops Protein synthesis concludes when a ribosome encounters a stop codon in a transcript, which triggers the recruitment of highly conserved release factors to liberate the protein product. Lawson et al. used traditional… read more here.
Keywords: release factors; translation; translation termination; termination ... See more keywords
Molecular basis of translation termination at noncanonical stop codons in human mitochondria
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DOI: 10.1126/science.adf9890
Abstract: The genetic code that specifies the identity of amino acids incorporated into proteins during protein synthesis is almost universally conserved. Mitochondrial genomes feature deviations from the standard genetic code, including the reassignment of two arginine… read more here.
Keywords: stop codons; noncanonical stop; microscopy; termination ... See more keywords
Global analysis of translation termination in E. coli
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DOI: 10.1371/journal.pgen.1006676
Abstract: Terminating protein translation accurately and efficiently is critical for both protein fidelity and ribosome recycling for continued translation. The three bacterial release factors (RFs) play key roles: RF1 and 2 recognize stop codons and terminate… read more here.
Keywords: global analysis; translation; translation termination; stop codons ... See more keywords
In eubacteria, unlike eukaryotes, there is no evidence for selection favouring fail-safe 3’ additional stop codons
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DOI: 10.1371/journal.pgen.1008386
Abstract: Errors throughout gene expression are likely deleterious, hence genomes are under selection to ameliorate their consequences. Additional stop codons (ASCs) are in-frame nonsense ‘codons’ downstream of the primary stop which may be read by translational… read more here.
Keywords: fail safe; additional stop; evidence; primary stop ... See more keywords
Efficient Simultaneous Introduction of Premature Stop Codons in Three Tumor Suppressor Genes in PFFs via a Cytosine Base Editor
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DOI: 10.3390/genes13050835
Abstract: Base editing is an efficient and precise gene-editing technique, by which a single base can be changed without introducing double-strand breaks, and it is currently widely used in studies of various species. In this study,… read more here.
Keywords: premature stop; stop codons; base; tri mut ... See more keywords
Analysis of Stop Codons within Prokaryotic Protein-Coding Genes Suggests Frequent Readthrough Events
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DOI: 10.3390/ijms22041876
Abstract: Nonsense mutations turn a coding (sense) codon into an in-frame stop codon that is assumed to result in a truncated protein product. Thus, nonsense substitutions are the hallmark of pseudogenes and are used to identify… read more here.
Keywords: protein; frame stop; codons within; protein coding ... See more keywords