Trifluoperazine Elevates Intracellular Ca2+ Levels and Locks Open the Store‐Operated Calcium Entry Channels in Astrocytes
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DOI: 10.1002/glia.70052
Abstract: Trifluoperazine (TFP), a known inhibitor of Ca2+‐bound calmodulin (Ca2+/CaM), has been reported to elevate cytosolic Ca2+ levels by disinhibiting inositol 1,4,5‐triphosphate receptor 2 (IP3R2), thereby suppressing glioblastoma invasion and inducing apoptosis. Interestingly, TFP induces a… read more here.
Keywords: ca2 levels; store operated; ca2; sustained ca2 ... See more keywords
Fluorescence-Based Measurements of Store-Operated Ca2+ Entry in Cancer Cells Using Fluo-4 and Confocal Live-Cell Imaging.
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DOI: 10.1007/978-1-4939-8704-7_5
Abstract: The store-operated calcium entry (SOCE) is the predominant calcium entry mechanism in cancer cell and other non-exciting cells. In the last few years, there is rapidly accumulating evidence supporting that SOCE is dysregulated in many… read more here.
Keywords: store operated; based measurements; fluorescence based; entry ... See more keywords
Molecular Basis and Regulation of Store-Operated Calcium Entry.
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DOI: 10.1007/978-3-030-12457-1_17
Abstract: Store-operated Ca2+ entry (SOCE) is a ubiquitous mechanism for Ca2+ influx in mammalian cells with important physiological implications. Since the discovery of SOCE more than three decades ago, the mechanism that communicates the information about… read more here.
Keywords: store operated; molecular basis; basis regulation; ca2 ... See more keywords
Pathophysiological Significance of Store-Operated Calcium Entry in Cardiovascular and Skeletal Muscle Disorders and Angiogenesis.
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DOI: 10.1007/978-3-030-12457-1_19
Abstract: Store-Operated Ca2+ Entry (SOCE) is an important Ca2+ influx pathway expressed by several excitable and non-excitable cell types. SOCE is recognized as relevant signaling pathway not only for physiological process, but also for its involvement… read more here.
Keywords: skeletal muscle; store operated; cardiovascular skeletal; significance ... See more keywords
The Role of Mitochondria in the Activation/Maintenance of SOCE: Membrane Contact Sites as Signaling Hubs Sustaining Store-Operated Ca2+ Entry.
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DOI: 10.1007/978-3-319-57732-6_15
Abstract: Store-operated Ca2+ entry (SOCE) is a cell signaling pathway essential for immune and muscle function controlled by dynamic interactions between Ca2+-sensing STIM proteins on the endoplasmic reticulum (ER) and Ca2+-permeable ORAI channels on the plasma… read more here.
Keywords: store operated; contact sites; membrane contact; operated ca2 ... See more keywords
STIM-TRP Pathways and Microdomain Organization: Contribution of TRPC1 in Store-Operated Ca2+ Entry: Impact on Ca2+ Signaling and Cell Function.
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DOI: 10.1007/978-3-319-57732-6_9
Abstract: Store-operated calcium entry (SOCE) is a ubiquitous Ca2+ entry pathway that is activated in response to depletion of ER-Ca2+ stores and critically controls the regulation of physiological functions in a wide variety of cell types.… read more here.
Keywords: store operated; trpc1; function; store ... See more keywords
Electrophysiological Features of Single Store-Operated Calcium Channels in HEK S4 Cell Line with Stable STIM1 Protein Knockdown
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DOI: 10.1007/s10517-017-3795-x
Abstract: An important role in intracellular calcium signaling is played by store-operated channels activated by STIM proteins, calcium sensors of the endoplasmic reticulum. In stable STIM1 knockdown HEK S4 cells, single channels activated by depletion of… read more here.
Keywords: calcium; store operated; stable stim1; operated calcium ... See more keywords
Store-Operated Calcium Entry in Mouse Cardiomyocytes
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DOI: 10.1007/s10517-019-04516-x
Abstract: The fluorescent dye fura-2 AM was employed to record activation of Ca2+ entry in response to a decrease in Ca2+ concentration in the endoplasmic reticulum. Using whole-cell voltage clamp technique, we revealed Ca2+ currents with… read more here.
Keywords: store operated; calcium entry; entry mouse; entry ... See more keywords
Astroglial Ca2+ signaling is generated by the coordination of IP3R and store-operated Ca2+ channels.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.03.096
Abstract: Astrocytes play key roles in the central nervous system and regulate local blood flow and synaptic transmission via intracellular calcium (Ca2+) signaling. Astrocytic Ca2+ signals are generated by multiple pathways: Ca2+ release from the endoplasmic… read more here.
Keywords: store operated; ca2 signaling; astrocytic ca2; ca2 ... See more keywords
Reversal of phosphate-induced ORAI1 expression, store-operated Ca2+ entry and osteogenic signaling by MgCl2 in human aortic smooth muscle cells.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.11.005
Abstract: In chronic kidney disease, renal phosphate retention leads to hyperphosphatemia with subsequent vascular osteogenic signaling and calcification. Osteogenic signaling involves up-regulation of the transcription factors CBFA1, MSX2, and SOX9, as well as alkaline phosphatase (ALP),… read more here.
Keywords: store operated; osteogenic signaling; muscle cells; smooth muscle ... See more keywords
Role of ORAI Proteins in Activation of Endogenous TRPC1-Composed Channels
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DOI: 10.1016/j.bpj.2016.11.2621
Abstract: Depletion of intracellular calcium stores activates store-operated channels. This process induces numerous intracellular signaling events. The most studied store-operated channels are CRAC channels. Other channels are believed to consist of TRPC and Orai proteins. However,… read more here.
Keywords: store operated; proteins activation; role orai; role ... See more keywords