Cold stored platelets in the management of bleeding: is it about bioenergetics?
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DOI: 10.1080/09537104.2023.2188969
Abstract: When platelet concentrates (PCs) were first introduced in the 1960s as a blood component therapy, they were stored in the cold. As platelet transfusion became more important for the treatment of chemotherapy-induced thrombocytopenia, research into… read more here.
Keywords: platelets management; management bleeding; stored platelets; platelet ... See more keywords
Metabolic phenotypes of standard and cold‐stored platelets
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DOI: 10.1111/trf.15651
Abstract: Conventional platelet (PLT) storage at room temperature under continuous agitation results in a limited shelf life (5 days) and an increased risk of bacterial contamination. However, both of these aspects can be ameliorated by cold storage.… read more here.
Keywords: cold stored; stored platelets; room temperature; phenotypes standard ... See more keywords
Cofilin‐1–induced actin reorganization in stored platelets
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DOI: 10.1111/trf.15747
Abstract: During platelet storage, there are extensive changes in cytoskeleton and phosphatidylserine exposure. The intrinsic mitochondrial pathway of apoptosis, activated in stored platelets, is a major mediator these changes. Cofilin‐1 is an effector of actin reorganization.… read more here.
Keywords: reorganization stored; stored platelets; induced actin; actin reorganization ... See more keywords
Cold‐stored platelets have better preserved contractile function in comparison with room temperature‐stored platelets over 21 days
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DOI: 10.1111/trf.16530
Abstract: Although it is well established that transfusion of platelets in cases of severe bleeding reduces mortality, the availability of platelets is hampered by harsh restrictions on shelf life due to elevated risks of microbial contamination… read more here.
Keywords: cold stored; stored platelets; room temperature; contractile function ... See more keywords
Cold‐stored platelets are effective in an in vitro model of massive transfusion protocol assessed by rotational thromboelastometry
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DOI: 10.1111/trf.16974
Abstract: Platelets are a key component of massive transfusion in treating actively bleeding patients. While optimized for prophylactic transfusions, the effectiveness of the current standard room temperature stored platelets (RPs) in treating actively bleeding patients is… read more here.
Keywords: massive transfusion; model; stored platelets; transfusion ... See more keywords
Donor variation in stored platelets: Higher metabolic rates of platelets are associated with mean platelet volume, activation and donor health
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DOI: 10.1111/trf.17160
Abstract: Platelets (PLTs) differ in glycolytic activity, resulting in rapid acidification of ‘poor’ storing PLT concentrates (PCs) in plasma, or depletion of glucose when stored in PLT additive solution (PAS). We aimed to understand why PLT… read more here.
Keywords: donor; higher metabolic; stored platelets; platelets higher ... See more keywords
The Missing Pieces to the Cold-Stored Platelet Puzzle
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DOI: 10.3390/ijms23031100
Abstract: Cold-stored platelets are making a comeback. They were abandoned in the late 1960s in favor of room-temperature stored platelets due to the need for longer post-transfusion platelet recoverability and survivability in patients with chronic thrombocytopenia.… read more here.
Keywords: pieces cold; missing pieces; stored platelets; cold stored ... See more keywords