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   Articles with "stored platelets" as a keyword



Cold stored platelets in the management of bleeding: is it about bioenergetics?

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recommendations! Published in 2023 at "Platelets"

DOI: 10.1080/09537104.2023.2188969

Abstract: When platelet concentrates (PCs) were first introduced in the 1960s as a blood component therapy, they were stored in the cold. As platelet transfusion became more important for the treatment of chemotherapy-induced thrombocytopenia, research into… read more here.

Keywords: platelets management; management bleeding; stored platelets; platelet ... See more keywords

A-123 Nascent ADAM17 synthesis potentiates GPIba cleavage in resting and stimulated stored platelets

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recommendations! Published in 2025 at "Clinical Chemistry"

DOI: 10.1093/clinchem/hvaf086.119

Abstract: Platelet concentrates stored at room temperature have a shelf life of five days. During storage, platelets undergo glycoprotein cleavage by metalloproteases, notably ADAM17 cleavage of GPIba, which leads to decreased post-transfusion reactivity and recovery. Aim:… read more here.

Keywords: stored platelets; adam17 synthesis; storage; gpiba ... See more keywords
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Metabolic phenotypes of standard and cold‐stored platelets

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recommendations! Published in 2019 at "Transfusion"

DOI: 10.1111/trf.15651

Abstract: Conventional platelet (PLT) storage at room temperature under continuous agitation results in a limited shelf life (5 days) and an increased risk of bacterial contamination. However, both of these aspects can be ameliorated by cold storage.… read more here.

Keywords: cold stored; stored platelets; room temperature; phenotypes standard ... See more keywords
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Cofilin‐1–induced actin reorganization in stored platelets

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recommendations! Published in 2020 at "Transfusion"

DOI: 10.1111/trf.15747

Abstract: During platelet storage, there are extensive changes in cytoskeleton and phosphatidylserine exposure. The intrinsic mitochondrial pathway of apoptosis, activated in stored platelets, is a major mediator these changes. Cofilin‐1 is an effector of actin reorganization.… read more here.

Keywords: reorganization stored; stored platelets; induced actin; actin reorganization ... See more keywords

Cold‐stored platelets have better preserved contractile function in comparison with room temperature‐stored platelets over 21 days

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recommendations! Published in 2021 at "Transfusion"

DOI: 10.1111/trf.16530

Abstract: Although it is well established that transfusion of platelets in cases of severe bleeding reduces mortality, the availability of platelets is hampered by harsh restrictions on shelf life due to elevated risks of microbial contamination… read more here.

Keywords: cold stored; stored platelets; room temperature; contractile function ... See more keywords

Cold‐stored platelets are effective in an in vitro model of massive transfusion protocol assessed by rotational thromboelastometry

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recommendations! Published in 2022 at "Transfusion"

DOI: 10.1111/trf.16974

Abstract: Platelets are a key component of massive transfusion in treating actively bleeding patients. While optimized for prophylactic transfusions, the effectiveness of the current standard room temperature stored platelets (RPs) in treating actively bleeding patients is… read more here.

Keywords: massive transfusion; model; stored platelets; transfusion ... See more keywords

Donor variation in stored platelets: Higher metabolic rates of platelets are associated with mean platelet volume, activation and donor health

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recommendations! Published in 2022 at "Transfusion"

DOI: 10.1111/trf.17160

Abstract: Platelets (PLTs) differ in glycolytic activity, resulting in rapid acidification of ‘poor’ storing PLT concentrates (PCs) in plasma, or depletion of glucose when stored in PLT additive solution (PAS). We aimed to understand why PLT… read more here.

Keywords: donor; higher metabolic; stored platelets; platelets higher ... See more keywords

Making cold platelets even cooler: Freezing cold-stored platelets to maximize inventory potential.

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recommendations! Published in 2025 at "Transfusion"

DOI: 10.1111/trf.70005

Abstract: BACKGROUND AND OBJECTIVES Refrigeration and cryopreservation are attractive alternatives that could support an extension of the current room temperature shelf life of platelets. As transfusion of cold-stored platelets (CSP) is currently limited to bleeding patients,… read more here.

Keywords: making cold; csp; stored platelets; shelf life ... See more keywords

Characterization of the in vitro quality parameters of cold‐stored platelets containing aggregates

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recommendations! Published in 2025 at "Vox Sanguinis"

DOI: 10.1111/vox.70064

Abstract: Cold‐stored platelets (CSP) are being used more widely for the treatment of bleeding because of their longer shelf life. However, storage at low temperatures can induce the formation of platelet aggregates. We aimed to study… read more here.

Keywords: stored platelets; characterization vitro; quality parameters; cold stored ... See more keywords

Impact of a rapid blood warmer on the quality and function of cold‐stored platelets

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recommendations! Published in 2025 at "Vox Sanguinis"

DOI: 10.1111/vox.70094

Abstract: Pre‐hospital critical care faces challenges in carrying platelet concentrates (PC). Cold‐stored platelets (CSP) may offer improved haemostatic function over room temperature platelets. Rapid warming of blood products is crucial for hypothermic trauma patients. This study… read more here.

Keywords: stored platelets; function; blood; cold stored ... See more keywords

Reduction of Lactate Production By Phospholipase C Inhibition in Cold Stored Platelets

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recommendations! Published in 2024 at "Blood"

DOI: 10.1182/blood-2024-200969

Abstract: Introduction: Anaerobic glycolysis and resultant lactic acid accumulation have been shown to impair platelet function during cold storage. The goal of current study is to understand the contribution of phospholipase C (PLC) activity to glucose… read more here.

Keywords: vehicle; stored platelets; storage; lactate production ... See more keywords