The strain-promoted alkyne-nitrone and alkyne-nitrile oxide cycloaddition reactions: A theoretical study
Sign Up to like & getrecommendations! Published in 2017 at "Tetrahedron"
DOI: 10.1016/j.tet.2017.06.038
Abstract: Abstract Density functional theory (DFT) calculations were performed to study the mechanism of bioorthogonal strain-promoted dibenzocyclooctyne (DIBO)-nitrone and DIBO-nitrile oxide cycloaddition (CA) reactions at B3LYP/6-31G(d,p), M06-2X/6-31G(d,p) and B3LYP-D3/6-31G(d,p) levels of theory. The potential energy surface… read more here.
Keywords: cycloaddition reactions; nitrile oxide; study; strain promoted ... See more keywords
Modular PET Agent Construction Strategy through Strain-Promoted Double-Click Reagent with Efficient Photoclick Step.
Sign Up to like & getrecommendations! Published in 2022 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.2c00427
Abstract: An efficient modular strategy for rapid assembly of positron emission tomography (PET) agents has been developed. The use of a sequential, rapid, and selective double-click reaction allows for a combinatorial approach to the cross-linking of… read more here.
Keywords: pet; pet agents; strategy; strain promoted ... See more keywords
Rapid Synthesis of Functionalized High-Generation Polyester Dendrimers via Strain-Promoted Alkyne–Azide Cycloaddition
Sign Up to like & getrecommendations! Published in 2017 at "Macromolecules"
DOI: 10.1021/acs.macromol.7b01765
Abstract: Preparation of structurally perfect high-generation dendrimer libraries with different peripheral groups is challenging as divergent synthesis introduces peripheral defects and convergent synthesis leads to low yields. Here, we prepare a third-generation polyester dendron based on… read more here.
Keywords: generation polyester; high generation; generation; strain promoted ... See more keywords
Functionalized Double Strain-Promoted Stapled Peptides for Inhibiting the p53-MDM2 Interaction
Sign Up to like & getrecommendations! Published in 2020 at "ACS Omega"
DOI: 10.1021/acsomega.9b03459
Abstract: The Sondheimer dialkyne reagent has previously been employed in strain-promoted double-click cycloadditions with bis-azide peptides to generate stapled peptide inhibitors of protein-protein interactions. The substituted variants of the Sondheimer dialkyne can be used to generate… read more here.
Keywords: sondheimer dialkyne; strain promoted; stapled peptide; p53 mdm2 ... See more keywords
Effect of Resonance on the Clickability of Alkenyl Azides in the Strain-promoted Cycloaddition with Dibenzo-fused Cyclooctynes
Sign Up to like & getrecommendations! Published in 2019 at "Chemistry Letters"
DOI: 10.1246/cl.190400
Abstract: The clickabilities of various alkenyl and alkyl azides in the strain-promoted cycloaddition with dibenzo-fused cyclooctynes were investigated. Although alkenyl azides generally exhibited lower clic... read more here.
Keywords: fused cyclooctynes; azides strain; strain promoted; dibenzo fused ... See more keywords