Strain-Specific Propagation by an Amyloid-Beta Dodecamer
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.1962
Abstract: Soluble oligomers of the amyloid-β (Aβ) peptide have emerged as the primary neurotoxic agents in Alzheimer disease (AD). Increasing evidence implicates aggregates of Aβ to propagate towards fibrils in a strain-specific manner. Morphological differences observed… read more here.
Keywords: propagation; seed; dodecamer; specific propagation ... See more keywords
Precise and Programmable Detection of Mutations Using Ultraspecific Riboregulators
Sign Up to like & getrecommendations! Published in 2020 at "Cell"
DOI: 10.1016/j.cell.2020.10.020
Abstract: (Cell 180, 1018–1032.e1–e16; March 5, 2020) Our paper reported the development of programmable RNA-based sensors for detection of specific mutations. Figure 6D presents application of the sensors to distinguish between different strains of Zika virus.… read more here.
Keywords: figure; rna; paper; specific snipr ... See more keywords
The impact of strain-specific immunity on Lyme disease incidence is spatially heterogeneous.
Sign Up to like & getrecommendations! Published in 2017 at "Diagnostic microbiology and infectious disease"
DOI: 10.1016/j.diagmicrobio.2017.08.015
Abstract: Lyme disease, caused by the bacterium Borrelia burgdorferi, is the most common tick-borne infection in the US. Recent studies have demonstrated that the incidence of human Lyme disease would have been even greater were it… read more here.
Keywords: specific immunity; lyme disease; strain specific; disease ... See more keywords
RNase 1, 2, 5 & 8 role in innate immunity: Strain specific antimicrobial activity.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2020.06.001
Abstract: The increase in microbial resistance to conventional antimicrobial agents is driving research for the discovery of new antibiotics and antifungal agents. The greatest challenge in this endeavor is to find antimicrobial agents with broad antimicrobial… read more here.
Keywords: specific antimicrobial; antimicrobial activity; activity rnase; strain specific ... See more keywords
Evidence for strain-specific virulence of Trichomonas gallinae in African columbiformes
Sign Up to like & getrecommendations! Published in 2022 at "Parasitology"
DOI: 10.1017/s0031182022001652
Abstract: Abstract Abstract Infection by parasites or pathogens can have marked physiological impacts on individuals. In birds, infection may affect moult and feather growth, which is an energetically demanding time in the annual cycle. Previous work… read more here.
Keywords: infection; strain specific; trichomonas gallinae; strain ... See more keywords
In vivo microscopic voxel-based morphometry with a brain template to characterize strain-specific structures in the mouse brain
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-00148-1
Abstract: Hundreds of inbred mouse strains are established for use in a broad spectrum of basic research fields, including genetics, neuroscience, immunology, and cancer. Inbred mice exhibit identical intra-strain genetics and divergent inter-strain phenotypes. The cognitive… read more here.
Keywords: vivo microscopic; strain specific; voxel based; strain ... See more keywords
Genetic variability of the U5 and downstream sequence of major HIV-1 subtypes and circulating recombinant forms
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-70083-1
Abstract: The critical role of the regulatory elements at the 5′ end of the HIV-1 genome in controlling the life cycle of HIV-1 indicates that this region significantly influences virus fitness and its biological properties. In… read more here.
Keywords: hiv; variability; strain specific; strain ... See more keywords
Computational design of CRISPR guide RNAs to enable strain-specific control of microbial consortia.
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2213154120
Abstract: Microbes naturally coexist in complex, multistrain communities. However, extracting individual microbes from and specifically manipulating the composition of these consortia remain challenging. The sequence-specific nature of CRISPR guide RNAs can be leveraged to accurately differentiate… read more here.
Keywords: crispr guide; crispr; strain specific; consortia ... See more keywords
Mouse strain-specific acute respiratory effects of nicotine unrelated to nicotine metabolism
Sign Up to like & getrecommendations! Published in 2019 at "Toxicology Mechanisms and Methods"
DOI: 10.1080/15376516.2019.1628141
Abstract: Abstract Plethysmograph measurement of respiratory phenotypes provides a highly sensitive means to study nicotine response in experimental model animals. We measured average respiratory frequency, tidal volume, minute volume and inspiratory time in C3H/HeJ and C57BL/6J… read more here.
Keywords: acute respiratory; mouse strain; strain specific; specific acute ... See more keywords
Rapid Intraspecies Evolution of Fitness Effects of Yeast Genes
Sign Up to like & getrecommendations! Published in 2022 at "Genome Biology and Evolution"
DOI: 10.1093/gbe/evac061
Abstract: Abstract Organisms within species have numerous genetic and phenotypic variations. Growing evidences show intraspecies variation of mutant phenotypes may be more complicated than expected. Current studies on intraspecies variations of mutant phenotypes are limited to… read more here.
Keywords: strain specific; fitness effects; intraspecies variation; fitness effect ... See more keywords
Genome-scale metabolic network reconstructions of diverse Escherichia strains reveal strain-specific adaptations
Sign Up to like & getrecommendations! Published in 2022 at "Philosophical Transactions of the Royal Society B: Biological Sciences"
DOI: 10.1098/rstb.2021.0236
Abstract: Bottom-up approaches to systems biology rely on constructing a mechanistic basis for the biochemical and genetic processes that underlie cellular functions. Genome-scale network reconstructions of metabolism are built from all known metabolic reactions and metabolic… read more here.
Keywords: scale metabolic; network; strain specific; network reconstructions ... See more keywords