The emerging role of homologous recombination repair and PARP inhibitors in genitourinary malignancies
Sign Up to like & getrecommendations! Published in 2017 at "Cancer"
DOI: 10.1002/cncr.30631
Abstract: As cells age and are exposed to genotoxic stress, preservation of the genomic code requires multiple DNA repair pathways to remove single‐strand or double‐strand breaks. Loss of function somatic genomic aberrations or germline deficiency in… read more here.
Keywords: parp inhibitors; genitourinary malignancies; homologous recombination; strand ... See more keywords
N‐terminal β‐strand in YAP is critical for stronger binding to scalloped relative to TEAD transcription factor
Sign Up to like & getrecommendations! Published in 2023 at "Protein Science"
DOI: 10.1002/pro.4545
Abstract: The yes‐associated protein (YAP) regulates the transcriptional activity of the TEAD transcription factors that are key in the control of organ morphogenesis. YAP interacts with TEAD via three secondary structure elements: a β‐strand, an α‐helix,… read more here.
Keywords: binding; strand; affinity; tead transcription ... See more keywords
Exploring 5'-Biotinylation of the Sense Strand to Improve siRNA Specificity and Potency.
Sign Up to like & getrecommendations! Published in 2020 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0290-4_9
Abstract: Although RNA interference is widely used for gene silencing, unintended gene modulation generated by off-target effects represents a major barrier to its applications in biology and medicine. Off-targeting can be induced by both the sense and antisense… read more here.
Keywords: sense strand; potency; sense; strand ... See more keywords
Strand-Specific Analysis of DNA Synthesis and Proteins Association with DNA Replication Forks in Budding Yeast.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7306-4_17
Abstract: DNA replication initiates at DNA replication origins after unwinding of double-strand DNA(dsDNA) by replicative helicase to generate single-stranded DNA (ssDNA) templates for the continuous synthesis of leading-strand and the discontinuous synthesis of lagging-strand. Therefore, methods… read more here.
Keywords: strand specific; dna; dna replication; strand ... See more keywords
Relative Quantification of siRNA Strand Loading into Ago2 for Design of Highly Active siRNAs.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9220-1_4
Abstract: In RNA interference (RNAi), silencing is achieved through the interaction of double-stranded small interfering RNAs (siRNAs) with essential RNAi pathway proteins, including Argonaute 2 (Ago2). Based on these interactions, one strand of the siRNA is… read more here.
Keywords: loading ago2; sirna strand; strand; relative quantification ... See more keywords
Effect of chemical and thermal modification, and material replacement on strand board properties
Sign Up to like & getrecommendations! Published in 2020 at "European Journal of Wood and Wood Products"
DOI: 10.1007/s00107-020-01527-8
Abstract: The purpose of this paper was to analyze the effects of various OSB-strand modifications on physical and mechanical properties of strand board. Norway spruce ( Picea abies L. Karst) strands were acetylated using acetic anhydride… read more here.
Keywords: water; strand; mechanical properties; strand board ... See more keywords
Purkinje physiology and pathophysiology
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Interventional Cardiac Electrophysiology"
DOI: 10.1007/s10840-018-0414-3
Abstract: There has always been an appreciation of the role of Purkinje fibers in the fast conduction of the normal cardiac impulse. Here, we briefly update our knowledge of this important set of cardiac cells. We… read more here.
Keywords: purkinje physiology; strand; physiology pathophysiology; physiology ... See more keywords
The Influence of Dispersedly Distributed Cracks on Critical Current of the Nb3Sn Strand
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Superconductivity and Novel Magnetism"
DOI: 10.1007/s10948-017-4362-4
Abstract: The Nb3Sn strand is the presently most widely used high field superconductor. However, one important fact is that the transport properties of an Nb3Sn strand will degrade obviously when it is subjected to high mechanical… read more here.
Keywords: strand; cracks critical; influence; critical current ... See more keywords
Partitioning of Clamping Strains in a Nineteen Parallel Wire Strand
Sign Up to like & getrecommendations! Published in 2017 at "Experimental Mechanics"
DOI: 10.1007/s11340-017-0276-0
Abstract: We report the first direct measurements of clamping strains within individual wires of a 19 parallel wire strand constrained by a clamshell clamp. In these measurements neutron diffraction was used to determine the elastic strains… read more here.
Keywords: individual wires; clamping strains; strand; wire strand ... See more keywords
Stress and Friction Distribution around Slab Corner in Continuous Casting Mold with Different Corner Structures
Sign Up to like & getrecommendations! Published in 2018 at "Metallurgical and Materials Transactions B"
DOI: 10.1007/s11663-018-1210-2
Abstract: The non-uniform friction and thermal stress in the mold are important as causes of the transverse cracks around strand corner. To analyze the stress distribution features around strand corner, a three-dimensional thermo-elastoplastic finite-element mold model… read more here.
Keywords: friction; strand; stress; face ... See more keywords
Evaluation of initial prestress state in PS strand using the deformation characteristics of multi-strand anchor head
Sign Up to like & getrecommendations! Published in 2018 at "KSCE Journal of Civil Engineering"
DOI: 10.1007/s12205-017-0800-x
Abstract: Prestressed concrete (PSC) bridge resists to deflection and cracking by prestressing its concrete superstructure using steel strands. The initial prestress force introduced in the strands at the completion of the structure influences sensitively its long-term… read more here.
Keywords: strand; anchor head; prestress; initial prestress ... See more keywords