Impact of mitochondrial DNA mutations in multiple myeloma
Sign Up to like & getrecommendations! Published in 2020 at "Blood Cancer Journal"
DOI: 10.1038/s41408-020-0315-4
Abstract: Dear Editor, Most cancers have altered metabolism with increased uptake of glucose (i.e. the “Warburg effect”) attributed to defective mitochondria. In addition, mitochondria are associated with multiple key processes linked to tumourigenesis including apoptosis, cell… read more here.
Keywords: strand bias; supplementary fig; multiple myeloma; strand ... See more keywords
Human activation-induced deaminase lacks strong replicative strand bias or preference for cytosines in hairpin loops
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac296
Abstract: Abstract Activation-induced deaminase (AID) is a DNA-cytosine deaminase that mediates maturation of antibodies through somatic hypermutation and class-switch recombination. While it causes mutations in immunoglobulin heavy and light chain genes and strand breaks in the… read more here.
Keywords: strand bias; replicative strand; preference; deaminase ... See more keywords