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   Articles with "strand break" as a keyword



The role of double‐strand break repair, translesion synthesis, and interstrand crosslinks in colorectal cancer progression—clinicopathological data and survival

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recommendations! Published in 2019 at "Journal of Surgical Oncology"

DOI: 10.1002/jso.25737

Abstract: DNA repair is a new and important pathway that explains colorectal carcinogenesis. This study will evaluate the prognostic value of molecular modulation of double‐strand break repair (XRCC2 and XRCC5); DNA damage tolerance/translesion synthesis (POLH, POLK,… read more here.

Keywords: break repair; colorectal cancer; translesion synthesis; strand break ... See more keywords

A double-strand-break model for the relative biological effectiveness of electrons based on ionization clustering.

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recommendations! Published in 2022 at "Medical physics"

DOI: 10.1002/mp.15796

Abstract: BACKGROUND The effectiveness of ionizing radiation regarding DNA damage induction depends on its spatial energy deposition pattern. For electrons an increased effectiveness is observed at low kinetic energies due to the enhanced density of energy… read more here.

Keywords: biological effectiveness; model; double strand; relative biological ... See more keywords
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DNA Double-Strand Break-Induced Gene Amplification in Yeast.

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recommendations! Published in 2021 at "Methods in molecular biology"

DOI: 10.1007/978-1-0716-0644-5_17

Abstract: Precise control of the gene copy number in the model yeast Saccharomyces cerevisiae may facilitate elucidation of enzyme functions or, in cell factory design, can be used to optimize production of proteins and metabolites. Currently,… read more here.

Keywords: induced gene; dna double; strand break; double strand ... See more keywords

Introduction to the multi-author-review: emerging advances in the structural chemistry of DNA strand break repair

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recommendations! Published in 2019 at "Cellular and Molecular Life Sciences"

DOI: 10.1007/s00018-019-03364-2

Abstract: DNA strand breaks present a complex challenge for our cells, and the integrity of the DNA damage response machinery is critical for preventing cancer, premature aging, and neurodegenerative syndromes amongst other ailments. This multi-author review… read more here.

Keywords: chemistry; multi author; author review; strand break ... See more keywords

Reconsidering the Chemical Nature of Strand Breaks Derived from Abasic Sites in Cellular DNA: Evidence for 3'-Glutathionylation.

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recommendations! Published in 2022 at "Journal of the American Chemical Society"

DOI: 10.1021/jacs.2c02703

Abstract: The hydrolytic loss of coding bases from cellular DNA is a common and unavoidable reaction. The resulting abasic sites can undergo β-elimination of the 3'-phosphoryl group to generate a strand break with an electrophilic α,β-unsaturated… read more here.

Keywords: evidence; cellular dna; strand; strand break ... See more keywords

Base excision repair and double strand break repair cooperate to modulate the formation of unrepaired double strand breaks in mouse brain

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recommendations! Published in 2024 at "Nature Communications"

DOI: 10.1038/s41467-024-51906-5

Abstract: We lack the fundamental information needed to understand how DNA damage in the brain is generated and how it is controlled over a lifetime in the absence of replication check points. To address these questions,… read more here.

Keywords: brain; strand; repair; double strand ... See more keywords

The N-Myc-responsive lncRNA MILIP promotes DNA double-strand break repair through non-homologous end joining

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recommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.2208904119

Abstract: Significance Here, we report that the lncRNA MILIP is transcriptionally regulated by N-Myc and functions to promote DNA double-strand break repair in neuroblastoma cells. MILIP is distinguished from other lncRNAs implicated in DNA repair through… read more here.

Keywords: break repair; dna double; double strand; strand break ... See more keywords

Ubiquitin-induced RNF168 condensation promotes DNA double-strand break repair

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recommendations! Published in 2024 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.2322972121

Abstract: Significance We demonstrated that RNF168 underwent liquid–liquid phase separation at the double-strand break (DSB) sites driven by both the intrinsically disordered region and the interaction with K63-linked polyubiquitin chains. Irradiation-induced RNF168 condensation accelerated the accumulation… read more here.

Keywords: induced rnf168; strand break; rnf168 condensation; double strand ... See more keywords
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Schizosaccharomyces pombe KAT5 contributes to resection and repair of a DNA double strand break.

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recommendations! Published in 2021 at "Genetics"

DOI: 10.1093/genetics/iyab042

Abstract: Chromatin remodeling is essential for effective repair of a DNA double strand break. KAT5 (S. pombe Mst1, human TIP60) is a MYST family histone acetyltransferase conserved from yeast to humans that coordinates various DNA damage… read more here.

Keywords: strand break; double strand; dna; repair ... See more keywords

APTX acts in DNA double-strand break repair in a manner distinct from XRCC4

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recommendations! Published in 2023 at "Journal of Radiation Research"

DOI: 10.1093/jrr/rrad007

Abstract: Abstract Aprataxin (APTX), the product of the causative gene for hereditary neurogenerative syndromes Ataxia-oculomotor apraxia 1 and early onset ataxia with oculomotor apraxia and hypoalbuminemia, has an enzymatic activity of removing adenosine monophosphate from DNA… read more here.

Keywords: aptx; xrcc4; strand break; break repair ... See more keywords

DNA double-strand break repair capacity and normal tissue toxicity induced by radiotherapy

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recommendations! Published in 2024 at "Journal of Radiation Research"

DOI: 10.1093/jrr/rrae081

Abstract: Abstract Radiation therapy is used in the treatment of various cancers, and advancements in irradiation techniques have further expanded its applicability. For radiation oncologists, predicting adverse events remains a critical challenge, even with these technological… read more here.

Keywords: normal tissue; dna double; break repair; double strand ... See more keywords