The role of double‐strand break repair, translesion synthesis, and interstrand crosslinks in colorectal cancer progression—clinicopathological data and survival
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Surgical Oncology"
DOI: 10.1002/jso.25737
Abstract: DNA repair is a new and important pathway that explains colorectal carcinogenesis. This study will evaluate the prognostic value of molecular modulation of double‐strand break repair (XRCC2 and XRCC5); DNA damage tolerance/translesion synthesis (POLH, POLK,… read more here.
Keywords: break repair; colorectal cancer; translesion synthesis; strand break ... See more keywords
A double-strand-break model for the relative biological effectiveness of electrons based on ionization clustering.
Sign Up to like & getrecommendations! Published in 2022 at "Medical physics"
DOI: 10.1002/mp.15796
Abstract: BACKGROUND The effectiveness of ionizing radiation regarding DNA damage induction depends on its spatial energy deposition pattern. For electrons an increased effectiveness is observed at low kinetic energies due to the enhanced density of energy… read more here.
Keywords: biological effectiveness; model; double strand; relative biological ... See more keywords
DNA Double-Strand Break-Induced Gene Amplification in Yeast.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0644-5_17
Abstract: Precise control of the gene copy number in the model yeast Saccharomyces cerevisiae may facilitate elucidation of enzyme functions or, in cell factory design, can be used to optimize production of proteins and metabolites. Currently,… read more here.
Keywords: induced gene; dna double; strand break; double strand ... See more keywords
Introduction to the multi-author-review: emerging advances in the structural chemistry of DNA strand break repair
Sign Up to like & getrecommendations! Published in 2019 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-019-03364-2
Abstract: DNA strand breaks present a complex challenge for our cells, and the integrity of the DNA damage response machinery is critical for preventing cancer, premature aging, and neurodegenerative syndromes amongst other ailments. This multi-author review… read more here.
Keywords: chemistry; multi author; author review; strand break ... See more keywords
Reconsidering the Chemical Nature of Strand Breaks Derived from Abasic Sites in Cellular DNA: Evidence for 3'-Glutathionylation.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c02703
Abstract: The hydrolytic loss of coding bases from cellular DNA is a common and unavoidable reaction. The resulting abasic sites can undergo β-elimination of the 3'-phosphoryl group to generate a strand break with an electrophilic α,β-unsaturated… read more here.
Keywords: evidence; cellular dna; strand; strand break ... See more keywords
The N-Myc-responsive lncRNA MILIP promotes DNA double-strand break repair through non-homologous end joining
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2208904119
Abstract: Significance Here, we report that the lncRNA MILIP is transcriptionally regulated by N-Myc and functions to promote DNA double-strand break repair in neuroblastoma cells. MILIP is distinguished from other lncRNAs implicated in DNA repair through… read more here.
Keywords: break repair; dna double; double strand; strand break ... See more keywords
Schizosaccharomyces pombe KAT5 contributes to resection and repair of a DNA double strand break.
Sign Up to like & getrecommendations! Published in 2021 at "Genetics"
DOI: 10.1093/genetics/iyab042
Abstract: Chromatin remodeling is essential for effective repair of a DNA double strand break. KAT5 (S. pombe Mst1, human TIP60) is a MYST family histone acetyltransferase conserved from yeast to humans that coordinates various DNA damage… read more here.
Keywords: strand break; double strand; dna; repair ... See more keywords
APTX acts in DNA double-strand break repair in a manner distinct from XRCC4
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Radiation Research"
DOI: 10.1093/jrr/rrad007
Abstract: Abstract Aprataxin (APTX), the product of the causative gene for hereditary neurogenerative syndromes Ataxia-oculomotor apraxia 1 and early onset ataxia with oculomotor apraxia and hypoalbuminemia, has an enzymatic activity of removing adenosine monophosphate from DNA… read more here.
Keywords: aptx; xrcc4; strand break; break repair ... See more keywords
A multiplexed bioluminescent reporter for sensitive and non-invasive tracking of DNA double strand break repair dynamics in vitro and in vivo
Sign Up to like & getrecommendations! Published in 2020 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkaa669
Abstract: Abstract Tracking DNA double strand break (DSB) repair is paramount for the understanding and therapeutic development of various diseases including cancers. Herein, we describe a multiplexed bioluminescent repair reporter (BLRR) for non-invasive monitoring of DSB… read more here.
Keywords: dna; dna double; strand break; double strand ... See more keywords
HDGFRP3 interaction with 53BP1 promotes DNA double-strand break repair
Sign Up to like & getrecommendations! Published in 2023 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkad073
Abstract: Abstract The 53BP1-dependent end-joining pathway plays a critical role in double-strand break (DSB) repair. However, the regulators of 53BP1 in chromatin remain incompletely characterized. In this study, we identified HDGFRP3 (hepatoma-derived growth factor related protein… read more here.
Keywords: interaction; hdgfrp3; double strand; end ... See more keywords
RecBCD coordinates repair of two ends at a DNA double-strand break, preventing aberrant chromosome amplification
Sign Up to like & getrecommendations! Published in 2018 at "Nucleic Acids Research"
DOI: 10.1093/nar/gky463
Abstract: Abstract DNA double-strand break (DSB) repair is critical for cell survival. A diverse range of organisms from bacteria to humans rely on homologous recombination for accurate DSB repair. This requires both coordinate action of the… read more here.
Keywords: dna double; strand break; double strand; two ends ... See more keywords