Modulation effect of double strand DNA on the self-assembly of N-terminal domain of Euplotes octocarinatus centrin.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of inorganic biochemistry"
DOI: 10.1016/j.jinorgbio.2017.12.001
Abstract: Centrin is a member of the EF-hand super family of calcium-binding proteins, which can behave as a part of damage detector initiated the initiation of nucleotide excision repair (NER). Its self-assembly plays a causative role… read more here.
Keywords: terminal domain; self assembly; dna; strand dna ... See more keywords
SJP-L-5 inhibits HIV-1 polypurine tract primed plus-strand DNA elongation, indicating viral DNA synthesis initiation at multiple sites under drug pressure
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-20954-5
Abstract: In a previous study the small molecule SJP-L-5 that inhibits HIV replication, has been shown to block uncoating of the viral capsid. Continued study showed that SJP-L-5 might hinder HIV capsid uncoating by blocking the… read more here.
Keywords: dna synthesis; dna; strand dna; plus strand ... See more keywords
Stabilization of G-quadruplex DNA structures in Schizosaccharomyces pombe causes single-strand DNA lesions and impedes DNA replication
Sign Up to like & getrecommendations! Published in 2020 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkaa820
Abstract: Abstract G-quadruplex (G4) structures are stable non-canonical DNA structures that are implicated in the regulation of many cellular pathways. We show here that the G4-stabilizing compound PhenDC3 causes growth defects in Schizosaccharomyces pombe cells, especially… read more here.
Keywords: dna; schizosaccharomyces pombe; strand dna; dna structures ... See more keywords
DNA fragmentation of human spermatozoa: Simple assessment of single‐ and double‐strand DNA breaks and their respective dynamic behavioral response
Sign Up to like & getrecommendations! Published in 2020 at "Andrology"
DOI: 10.1111/andr.12819
Abstract: Procedures to detect sperm DNA fragmentation (SDF), like the sperm chromatin dispersion (SCD) test, determine the “global” SDF without discriminating between spermatozoa with single‐strand DNA breaks only (SDF‐SSBs) and those containing double‐strand DNA breaks (SDF‐DSBs). read more here.
Keywords: dna; strand dna; dna breaks; double strand ... See more keywords
Predicting double-strand DNA breaks using epigenome marks or DNA at kilobase resolution
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DOI: 10.1186/s13059-018-1411-7
Abstract: Double-strand breaks (DSBs) result from the attack of both DNA strands by multiple sources, including radiation and chemicals. DSBs can cause the abnormal chromosomal rearrangements associated with cancer. Recent techniques allow the genome-wide mapping of… read more here.
Keywords: resolution; predicting double; double strand; strand dna ... See more keywords
Specific Human ATR and ATM Inhibitors Modulate Single Strand DNA Formation in Leishmania major Exposed to Oxidative Agent
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2021.802613
Abstract: Leishmania parasites are the causative agents of a group of neglected tropical diseases known as leishmaniasis. The molecular mechanisms employed by these parasites to adapt to the adverse conditions found in their hosts are not… read more here.
Keywords: dna; atr; single strand; leishmania ... See more keywords