Cadherins can dimerize via asymmetric interactions
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DOI: 10.1002/1873-3468.14373
Abstract: Cadherins are essential cell–cell adhesion proteins that interact in two distinct conformations: X‐dimers and strand‐swap dimers. Both X‐dimers and strand‐swap dimers are thought to exclusively rely on symmetric sets of interactions between key amino acids… read more here.
Keywords: cadherins dimerize; cadherin binding; via asymmetric; swap dimers ... See more keywords
Multiple dimeric structures and strand-swap dimerization of E-cadherin in solution visualized by high-speed atomic force microscopy
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2208067119
Abstract: Significance E-cadherin is a major cell–cell adhesion molecule that connects opposing cells via extracellular domains (ectodomains) and regulates tissue morphology and dynamics. Mutual binding of the ectodomains has been considered to be formed by a… read more here.
Keywords: high speed; speed atomic; microscopy; cadherin ... See more keywords