Novel secondary mutations C56S and G149A confer resistance to HIV‐1 integrase strand transfer inhibitors
Sign Up to like & getrecommendations! Published in 2018 at "Antiviral Research"
DOI: 10.1016/j.antiviral.2018.01.013
Abstract: ABSTRACT Cabotegravir (CAB, S/GSK1265744) is an investigational second‐generation integrase strand transfer inhibitor (INSTI) with a chemical structure similar to dolutegravir. CAB is under development as a long‐acting injectable formulation for treatment of HIV‐1 infection and… read more here.
Keywords: integrase; c56s g149a; strand transfer; resistance ... See more keywords
Impact of 5'-end nucleotide modifications of HIV-1 genomic RNA on reverse transcription.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.06.152
Abstract: Reverse transcription of retroviral RNA is accomplished through a minus-strand strong stop cDNA (-sscDNA) synthesis and subsequent strand-transfer reactions. We have previously reported a critical role of guanosine (G) number at 5'-terminal of HIV-1 RNA… read more here.
Keywords: rna; strand transfer; strand; ggg tract ... See more keywords
Meta-analysis and systematic review of the efficacy and resistance for human immunodeficiency virus type 1 integrase strand transfer inhibitors.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of antimicrobial agents"
DOI: 10.1016/j.ijantimicag.2019.08.008
Abstract: Integrase strand transfer inhibitors (INSTIs) are the most recent class of antiretroviral drugs with potent and durable antiviral activity used to treat human immunodeficiency virus type 1 (HIV-1) infection. However, the development of drug resistance… read more here.
Keywords: efficacy; strand transfer; resistance; efficacy resistance ... See more keywords
HIV integrase inhibitors that inhibit strand transfer interact with RAG1 and hamper its activities.
Sign Up to like & getrecommendations! Published in 2021 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2021.107515
Abstract: Multiple steps of the retroviral infection process have been targeted over the years to develop therapeutic approaches, starting from the entry of the virus into the cell till the viral DNA integration to host genome.… read more here.
Keywords: integrase inhibitors; inhibit strand; inhibitors inhibit; strand transfer ... See more keywords
HIV-1 sequences in the epidemic suggest an alternative pathway for the generation of the Long Terminal Repeats
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DOI: 10.1038/s41598-017-14135-z
Abstract: To generate the long-terminal repeats (LTR) that border the integrated viral genome, two-strand transfer steps must occur during reverse transcription. Analysis of the genetic polymorphisms that are present in the LTR of HIV-1 heterozygous virions… read more here.
Keywords: terminal repeats; sequences epidemic; strand transfer; long terminal ... See more keywords
Human and nonclinical disposition of [14C]bictegravir, a potent integrase strand-transfer inhibitor for the treatment of HIV-1 infection
Sign Up to like & getrecommendations! Published in 2022 at "Xenobiotica"
DOI: 10.1080/00498254.2022.2159569
Abstract: Abstract Bictegravir (BIC) is a potent small-molecule integrase strand-transfer inhibitor (INSTI) and a component of Biktarvy®, a single-tablet combination regimen that is currently approved for the treatment of human immunodeficiency virus type 1 (HIV-1) infection.… read more here.
Keywords: transfer inhibitor; potent; integrase strand; strand transfer ... See more keywords
Integrase strand transfer inhibitors use in children with perinatal HIV-1 infection: a narrative review.
Sign Up to like & getrecommendations! Published in 2022 at "AIDS research and human retroviruses"
DOI: 10.1089/aid.2022.0039
Abstract: INTRODUCTION Integrase strand transfer inhibitors (INSTIs), including raltegravir (RAL), dolutegravir (DTG), elvitegravir (EVG), bictegravir (BIC), and cabotegravir (CAB), are increasingly used given excellent data on their efficacy, effectiveness, and tolerability profile in adults, while data… read more here.
Keywords: integrase strand; strand transfer; transfer inhibitors; narrative review ... See more keywords
Primary resistance against integrase strand transfer inhibitors in integrase strand transfer inhibitor-naive patients failing first- and second-line ART in Tanzania
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Antimicrobial Chemotherapy"
DOI: 10.1093/jac/dkac295
Abstract: Abstract Introduction Sub-Saharan African countries are introducing integrase strand transfer inhibitors (INSTIs) in their ART programmes as the preferred first-line regimen, and dolutegravir is the INSTI of choice due to its potency, tolerability and high… read more here.
Keywords: integrase strand; strand transfer; resistance; line ... See more keywords
Integrase strand transfer inhibitors and neuropsychiatric adverse events in a large prospective cohort
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Antimicrobial Chemotherapy"
DOI: 10.1093/jac/dky497
Abstract: OBJECTIVES To analyse the frequency and causes of treatment discontinuation in patients who were treated with an integrase strand transfer inhibitor (INSTI), with a focus on neuropsychiatric adverse events (NPAEs). METHODS Patients in 18 HIV… read more here.
Keywords: adverse events; strand transfer; discontinuation; integrase strand ... See more keywords
Canary in the Coal Mine? Transmitted Mutations Conferring Resistance to All Integrase Strand Transfer Inhibitors in a Treatment-Naive Patient
Sign Up to like & getrecommendations! Published in 2018 at "Open Forum Infectious Diseases"
DOI: 10.1093/ofid/ofy294
Abstract: Abstract Transmitted drug resistance to the integrase strand transfer inhibitor (INSTI) class of antiretrovirals is very rare. We present a case of a treatment-naive female patient with human immunodeficiency virus harboring resistance to all INSTIs,… read more here.
Keywords: strand transfer; resistance; resistance integrase; integrase strand ... See more keywords
Resistance in Patients Failing Integrase Strand Transfer Inhibitors: A Call to Replace Raltegravir With Dolutegravir in Third-Line Treatment in South Africa
Sign Up to like & getrecommendations! Published in 2019 at "Open Forum Infectious Diseases"
DOI: 10.1093/ofid/ofz377
Abstract: Abstract Data on integrase resistance patterns in low- and middle-income countries (LMICs) is scarce. We assessed genotypic drug resistance in 43 patients with virological failure on integrase strand transfer inhibitors (INSTIs) containing regimens as part… read more here.
Keywords: integrase; resistance patients; strand transfer; transfer inhibitors ... See more keywords