G‐quadruplex‐enhanced circular single‐stranded DNA (G4‐CSSD) adsorption of miRNA to inhibit colon cancer progression
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Medicine"
DOI: 10.1002/cam4.5721
Abstract: Chromosomal heterogeneity leads to the abnormal expression and mutation of tumor‐specific genes. Drugs targeting oncogenes have been extensively developed. However, given the random mutation of tumor suppressor genes, the development of its targeted drugs is… read more here.
Keywords: single stranded; quadruplex enhanced; stranded dna; enhanced circular ... See more keywords
An Efficient Bead‐captured Denaturation Method for Preparing Long Single‐stranded DNA
Sign Up to like & getrecommendations! Published in 2017 at "Journal of The Chinese Chemical Society"
DOI: 10.1002/jccs.201700142
Abstract: Previous methods to prepare single-stranded DNA (ssDNA) substrates are limited to short DNA lengths and inefficient. We have developed an efficient and rapid method to prepare long ssDNA substrates (up to 4000 nt) based on the… read more here.
Keywords: single stranded; dna; ssdna; bead captured ... See more keywords
The intrinsically disordered linker of E. coli SSB is critical for the release from single‐stranded DNA
Sign Up to like & getrecommendations! Published in 2017 at "Protein Science"
DOI: 10.1002/pro.3115
Abstract: The Escherichia coli single stranded DNA binding protein (SSB) is crucial for DNA replication, recombination and repair. Within each process, it has two seemingly disparate roles: it stabilizes single‐stranded DNA (ssDNA) intermediates generated during DNA… read more here.
Keywords: single stranded; dna; ssb; stranded dna ... See more keywords
Two different kinds of interaction modes of deaminase APOBEC3A with single‐stranded DNA in solution detected by nuclear magnetic resonance
Sign Up to like & getrecommendations! Published in 2021 at "Protein Science"
DOI: 10.1002/pro.4242
Abstract: APOBEC3A (A3A) deaminates deoxycytidine in target motif TC in a single‐stranded DNA (we termed it as TC DNA), which mortally mutates viral pathogens and immunoglobulins, and leads to the diversification and lethality of cancers. The… read more here.
Keywords: dna; stranded dna; two different; solution ... See more keywords
Single-Stranded DNA-Binding Proteins in the Archaea.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1290-3_2
Abstract: Single-stranded (ss) DNA-binding proteins are found in all three domains of life where they play vital roles in nearly all aspects of DNA metabolism by binding to and stabilizing exposed ssDNA and acting as platforms… read more here.
Keywords: single stranded; ssdna binding; binding; stranded dna ... See more keywords
Measuring the Complex Effects of the Single-Stranded DNA-Binding Protein gp2.5 on Primer Synthesis and Extension by the Bacteriophage T7 Replisome.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1290-3_21
Abstract: The single-stranded DNA-binding protein gp2.5 of bacteriophage T7 plays myriad functions in the replication of phage genomes. In addition to interacting with ssDNA, gp2.5 binds to the T7 DNA polymerase and primase/helicase proteins, regulating their… read more here.
Keywords: single stranded; gp2 primer; protein gp2; stranded dna ... See more keywords
Structural Characterization of a Single-Stranded DNA-Binding Protein: A Case Study of the ORF6 Protein from Bacteriophage Enc34.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1290-3_23
Abstract: In the quest to understand how single-stranded DNA-binding proteins function and evolve at a molecular level, determination of their high-resolution three-dimensional structure using methods such as X-ray crystallography is indispensable. Here we present a collection… read more here.
Keywords: single stranded; biology; stranded dna; binding protein ... See more keywords
Molecular Genetic Characterization of Mutagenesis Using a Highly Sensitive Single-Stranded DNA Reporter System in Budding Yeast.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7306-4_4
Abstract: Mutations are permanent alterations to the coding content of DNA. They are starting material for the Darwinian evolution of species by natural selection, which has yielded an amazing diversity of life on Earth. Mutations can… read more here.
Keywords: dna; reporter system; molecular genetic; highly sensitive ... See more keywords
The yeast Dbf4 Zn2+ finger domain suppresses single-stranded DNA at replication forks initiated from a subset of origins.
Sign Up to like & getrecommendations! Published in 2022 at "Current genetics"
DOI: 10.1007/s00294-022-01230-6
Abstract: Dbf4 is the cyclin-like subunit for the Dbf4-dependent protein kinase (DDK), required for activating the replicative helicase at DNA replication origin that fire during S phase. Dbf4 also functions as an adaptor, targeting the DDK… read more here.
Keywords: dna; zn2 finger; stranded dna; dna replication ... See more keywords
Pleomorphic archaeal viruses: the family Pleolipoviridae is expanding by seven new species
Sign Up to like & getrecommendations! Published in 2020 at "Archives of Virology"
DOI: 10.1007/s00705-020-04689-1
Abstract: Established in 2016, the family Pleolipoviridae comprises globally distributed archaeal viruses that produce pleomorphic particles. Pseudo-spherical enveloped virions of pleolipoviruses are membrane vesicles carrying a nucleic acid cargo. The cargo can be either a single-stranded… read more here.
Keywords: single stranded; family; stranded dna; family pleolipoviridae ... See more keywords
Single-stranded DNA generated by high temperature accepts protons and builds up mutagenic and carcinogenic strong acids.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular biology reports"
DOI: 10.1007/s11033-021-06804-0
Abstract: Malignancies are caused by genetic or environmental factors. Esophageal carcinoma can be triggered by consumption of hot food and beverages. Here we propose that high temperature is one of the culprits and it leads to… read more here.
Keywords: single stranded; mutagenic carcinogenic; dna; high temperature ... See more keywords