Protection of the Telomeric Junction by the Shelterin Complex
Sign Up to like & getrecommendations! Published in 2024 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.4c08649
Abstract: Shelterin serves critical roles in suppressing superfluous DNA damage repair pathways on telomeres. The junction between double-stranded telomeric tracts (dsTEL) and single-stranded telomeric overhang (ssTEL) is the most accessible region of the telomeric DNA. The… read more here.
Keywords: protection; sstel; junction; shelterin complex ... See more keywords
Dynamic folding and accessibility of telomeric overhang
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2211219119
Abstract: The evolution of linear chromosomes in eukaryotes poses several challenges for the natural ends of chromosomes, such as misrecognition as DNA damage repair (DDR) sites, DNA degradation, and incomplete DNA replication. A solution to these… read more here.
Keywords: single stranded; dna; accessibility; accessibility telomeric ... See more keywords
Dynamic topology of double-stranded telomeric DNA studied by single-molecule manipulation in vitro
Sign Up to like & getrecommendations! Published in 2020 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkaa479
Abstract: Abstract The dynamic topological structure of telomeric DNA is closely related to its biological function; however, no such structural information on full-length telomeric DNA has been reported due to difficulties synthesizing long double-stranded telomeric DNA.… read more here.
Keywords: single molecule; telomeric dna; stranded telomeric; double stranded ... See more keywords