Dynamic Strategic Bond Analysis Yields a Ten-Step Synthesis of 20-nor-Salvinorin A, a Potent κ-OR Agonist
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DOI: 10.1021/acscentsci.7b00488
Abstract: Salvinorin A (SalA) is a plant metabolite that agonizes the human kappa-opioid receptor (κ-OR) with high affinity and high selectivity over mu- and delta-opioid receptors. Its therapeutic potential has stimulated extensive semisynthetic studies and total… read more here.
Keywords: salvinorin; strategic bond; step synthesis; dynamic strategic ... See more keywords