Strategies for targeting cell surface proteins using multivalent conjugates and chemical biology.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in cell biology"
DOI: 10.1016/bs.mcb.2021.06.004
Abstract: Proper function of receptors on the cell surface is essential for homeostasis. Compounds that target cell surface receptors to address dysregulation have proven exceptionally successful as therapeutic agents; however, the development of compounds with the… read more here.
Keywords: cell surface; biology; strategies targeting; biology strategies ... See more keywords
Emerging roles of and therapeutic strategies targeting BRD4 in cancer.
Sign Up to like & getrecommendations! Published in 2019 at "Cellular immunology"
DOI: 10.1016/j.cellimm.2019.02.001
Abstract: The Bromodomain and Extra-terminal (BET) family of proteins were first recognized as important epigenetic regulators in inflammatory processes; however, there is increasing evidence to support the notion that BET proteins also play a critical role… read more here.
Keywords: bet proteins; emerging roles; strategies targeting; therapeutic strategies ... See more keywords
Strategies of Targeting CK2 in Drug Discovery: Challenges, Opportunities, and Emerging Prospects.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c01523
Abstract: CK2 (casein kinase 2) is a serine/threonine protein kinase that is ubiquitous in eukaryotic cells and plays important roles in a variety of cellular functions, including cell growth, apoptosis, circadian rhythms, DNA damage repair, transcription,… read more here.
Keywords: drug discovery; discovery challenges; ck2 drug; ck2 ... See more keywords
Novel antiplatelet strategies targeting VWF and GPIb
Sign Up to like & getrecommendations! Published in 2020 at "Platelets"
DOI: 10.1080/09537104.2020.1786038
Abstract: Abstract Von Willebrand factor has a pivotal role in primary hemostasis. Its role in thrombotic microangiopathies (TMA), as well as cardiovascular disease, has been demonstrated. Thrombotic thrombocytopenic purpura (TTP), a thrombotic microangiopathy, is a life-threatening… read more here.
Keywords: antiplatelet strategies; targeting vwf; novel antiplatelet; vwf gpib ... See more keywords
Strategies for targeting RNA with small molecule drugs
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Drug Discovery"
DOI: 10.1080/17460441.2022.2111414
Abstract: ABSTRACT Introduction Historically, therapeutic treatment of disease has been restricted to targeting proteins. Of the approximately 20,000 translated human proteins, approximately 1600 are associated with diseases. Strikingly, less than 15% of disease-associated proteins are predicted… read more here.
Keywords: small molecule; targeting rna; molecule; molecule drugs ... See more keywords
Antitumor strategies targeting macrophages: the importance of considering the differences in differentiation/polarization processes between human and mouse macrophages
Sign Up to like & getrecommendations! Published in 2022 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2022-005560
Abstract: Macrophages are the immune cells that accumulate the most in the majority of established tumors and this accumulation is associated with a poor prognosis. Tumor-associated macrophages (TAMs) produce inflammatory cytokines and growth factors that promote… read more here.
Keywords: human mouse; antitumor strategies; mouse macrophages; strategies targeting ... See more keywords
Strategies of targeting KRAS, challenging drug target.
Sign Up to like & getrecommendations! Published in 2022 at "Current pharmaceutical design"
DOI: 10.2174/1381612828666220506144046
Abstract: In the developed world, cancer is the most common cause of death. Among the 36 human genes of the RAS family, KRAS, NRAS, and HRAS play a prominent role in human cancer. KRAS belongs to… read more here.
Keywords: kras challenging; challenging drug; strategies targeting; targeting kras ... See more keywords
Strategies of Targeting Inflammasome in the Treatment of Systemic Lupus Erythematosus
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.894847
Abstract: Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by multiple organ dysfunction resulting from the production of multiple autoantibodies and adaptive immune system abnormalities involving T and B lymphocytes. In recent years, inflammasomes have… read more here.
Keywords: lupus erythematosus; treatment; systemic lupus; strategies targeting ... See more keywords
Highlights of Strategies Targeting Fibroblasts for Novel Therapies for Rheumatoid Arthritis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2022.846300
Abstract: Synovial fibroblasts of rheumatoid arthritis (RA) play a critical role in perpetuation of chronic inflammation by interaction with immune and inflammatory cells and in cartilage and bone invasion, but current therapies for RA are not… read more here.
Keywords: fibroblast targeted; rheumatoid arthritis; fibroblast; strategies targeting ... See more keywords
Strategies Targeting Type 2 Inflammation: From Monoclonal Antibodies to JAK-Inhibitors
Sign Up to like & getrecommendations! Published in 2021 at "Biomedicines"
DOI: 10.3390/biomedicines9101497
Abstract: Bronchial asthma and its frequent comorbidity chronic rhinosinusitis (CRS), are characterized by an inflammatory process at lower and upper respiratory tract, with a variability in terms of clinical presentations (phenotypes) and distinct underpin pathophysiological mechanisms… read more here.
Keywords: monoclonal antibodies; targeting type; strategies targeting; inflammatory process ... See more keywords
Strategies Targeting Hemagglutinin as a Universal Influenza Vaccine
Sign Up to like & getrecommendations! Published in 2021 at "Vaccines"
DOI: 10.3390/vaccines9030257
Abstract: Influenza virus has significant viral diversity, both through antigenic drift and shift, which makes development of a vaccine challenging. Current influenza vaccines are updated yearly to include strains predicted to circulate in the upcoming influenza… read more here.
Keywords: vaccine strategies; influenza vaccine; strategies targeting; universal influenza ... See more keywords