An integrated strategy to identify COVID‐19 causal genes and characteristics represented by LRRC37A2
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Medical Virology"
DOI: 10.1002/jmv.28585
Abstract: Genome‐wide association study (GWAS) could identify host genetic factors associated with coronavirus disease 2019 (COVID‐19). The genes or functional DNA elements through which genetic factors affect COVID‐19 remain uncharted. The expression quantitative trait locus (eQTL)… read more here.
Keywords: strategy identify; integrated strategy; causal genes; causal ... See more keywords
Stepwise Strategy to Identify Thrombin as a Hydrolytic Substrate for Nattokinase
Sign Up to like & getrecommendations! Published in 2022 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.2c00978
Abstract: Nattokinase (NK) is a serine protease with a potent thrombolytic activity that possesses multiple cardiovascular disease (CVD) preventative and treatment activities. In light of its advanced beneficial cardiovascular effects and its nature as a serine… read more here.
Keywords: hydrolytic substrate; stepwise strategy; strategy; strategy identify ... See more keywords
Combinatorial Biomaterials Discovery Strategy to Identify New Macromolecular Cryoprotectants
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DOI: 10.1021/acsmacrolett.0c00044
Abstract: Cryoprotective agents (CPAs) are typically solvents or small molecules, but there is a need for innovative CPAs to reduce toxicity and increase cell yield, for the banking and transport of cells. Here we use a… read more here.
Keywords: macromolecular cryoprotectants; strategy identify; identify new; discovery strategy ... See more keywords
An innovative strategy to identify new targets for delivering antibodies to the brain has led to the exploration of the integrin family
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0274667
Abstract: Background Increasing brain exposure of biotherapeutics is key to success in central nervous system disease drug discovery. Accessing the brain parenchyma is especially difficult for large polar molecules such as biotherapeutics and antibodies because of… read more here.
Keywords: strategy identify; blood brain; brain barrier; brain ... See more keywords