A new antithrombotic strategy: inhibition of the C‐terminal active site of protein disulfide isomerase
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Thrombosis and Haemostasis"
DOI: 10.1111/jth.13634
Abstract: Protein disulfide isomerase (PDI) was discovered over fifty years ago as an enzyme that forms disulfide bonds in newly synthesized proteins in the endoplasmic reticulum [1]. Twenty five years ago PDI was shown to be… read more here.
Keywords: disulfide isomerase; protein disulfide; strategy inhibition; new antithrombotic ... See more keywords
Can Nimesulide Nanoparticles Be a Therapeutic Strategy for the Inhibition of the KRAS/PTEN Signaling Pathway in Pancreatic Cancer?
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2021.594917
Abstract: Pancreatic cancer is an aggressive, devastating disease due to its invasiveness, rapid progression, and resistance to surgical, pharmacological, chemotherapy, and radiotherapy treatments. The disease develops from PanINs lesions that progress through different stages. KRAS mutations… read more here.
Keywords: therapeutic strategy; nanoparticles therapeutic; nimesulide nanoparticles; pancreatic cancer ... See more keywords