Application of Physiologically Based Pharmacokinetic Modeling in Preclinical Studies: A Feasible Strategy to Practice the Principles of 3Rs
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DOI: 10.3389/fphar.2022.895556
Abstract: Pharmacokinetic characterization plays a vital role in drug discovery and development. Although involving numerous laboratory animals with error-prone, labor-intensive, and time-consuming procedures, pharmacokinetic profiling is still irreplaceable in preclinical studies. With physiologically based pharmacokinetic (PBPK)… read more here.
Keywords: practice principles; based pharmacokinetic; feasible strategy; physiologically based ... See more keywords