An Oxidative Bioconjugation Strategy Targeted to a Genetically Encoded 5‐Hydroxytryptophan
Sign Up to like & getrecommendations! Published in 2018 at "ChemBioChem"
DOI: 10.1002/cbic.201800111
Abstract: Approaches that enable the chemoselective, covalent modification of proteins in a site‐specific manner have emerged as a powerful technology for a wide range of applications. The electron‐rich unnatural amino acid 5‐hydroxytryptophan was recently genetically encoded… read more here.
Keywords: bioconjugation strategy; oxidative bioconjugation; genetically encoded; strategy targeted ... See more keywords
Warhead Strategy for Targeted Protein S-Nitrosation.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.5c07409
Abstract: Protein post-translational modifications (PTMs) are critical factors in disease progression. While progress has been made in regulating disease-associated PTMs such as phosphorylation and acetylation, the approach to achieving targeted S-nitrosation for disease treatment, particularly in… read more here.
Keywords: targeted nitrosation; targeted protein; strategy targeted; nitrosation ... See more keywords
Alternating exosomes and their mimetics as an emergent strategy for targeted cancer therapy
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2022.939050
Abstract: Exosomes, a subtype of the class of extracellular vesicles and nano-sized particles, have a specific membrane structure that makes them an alternative proposition to combat with cancer through slight modification. As constituents of all most… read more here.
Keywords: exosomes mimetics; cancer; strategy targeted; emergent strategy ... See more keywords