A new strategy for the in vitro selection of stapled peptide inhibitors by mRNA display.
Sign Up to like & getrecommendations! Published in 2019 at "Chemical communications"
DOI: 10.1039/c8cc10192b
Abstract: Hydrocarbon stapled peptides are promising therapeutics for inhibition of intracellular protein-protein interactions. Here we develop a new high-throughput strategy for hydrocarbon stapled peptide discovery based on mRNA display of peptides containing α-methyl cysteine and cyclized… read more here.
Keywords: stapled peptide; vitro selection; mrna display; strategy vitro ... See more keywords