Effects of solar radiations on Stratum Corneum hydration: part I, protective role of Skin surface lipids.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of biophotonics"
DOI: 10.1002/jbio.202300055
Abstract: This study used Raman spectroscopy to develop a new approach to evaluate the effects of solar radiation on the stratum corneum (SC). The method measures the SC's hydration and dehydration kinetics by calculating the vOH/vCH… read more here.
Keywords: stratum corneum; role; skin surface; role skin ... See more keywords
Stratum corneum substantivity: drug development implications
Sign Up to like & getrecommendations! Published in 2018 at "Archives of Dermatological Research"
DOI: 10.1007/s00403-018-1841-9
Abstract: There are at least 15 factors that influence the ability of chemicals to penetrate the skin. Substantivity is yet another factor and allows penetrants to remain on and in skin for many days. As many… read more here.
Keywords: drug development; stratum corneum; corneum substantivity; substantivity drug ... See more keywords
Size-Dependent Absorption through Stratum Corneum by Drug-Loaded Liposomes.
Sign Up to like & getrecommendations! Published in 2021 at "Pharmaceutical research"
DOI: 10.1007/s11095-021-03079-9
Abstract: PURPOSE Topical treatment of various skin disorders requires drug absorption and penetration through the stratum corneum (SC) into the epidermis and dermis tissues. The use of nano-drug delivery systems including liposomes and lipid nanoparticles (SLNs)… read more here.
Keywords: drug; epidermis dermis; stratum corneum; absorption ... See more keywords
Assessment of dermal bioavailability: predicting the input function for topical glucocorticoids using stratum corneum sampling.
Sign Up to like & getrecommendations! Published in 2021 at "Drug delivery and translational research"
DOI: 10.1007/s13346-021-01064-8
Abstract: Predicting the dermal bioavailability of topically delivered drugs is challenging. In this work, minimally invasive stratum corneum (SC) sampling was used to quantify the delivery of betamethasone valerate (BMV) into the viable skin. Betnovate® cream… read more here.
Keywords: dermal bioavailability; corneum sampling; stratum corneum;
Permeability and microstructure of model stratum corneum lipid membranes containing ceramides with long (C16) and very long (C24) acyl chains.
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical chemistry"
DOI: 10.1016/j.bpc.2017.03.004
Abstract: The Stratum corneum (SC) prevents water loss from the body and absorption of chemicals. SC intercellular spaces contain ceramides (Cer), free fatty acids (FFA), cholesterol (Chol) and cholesteryl sulfate (CholS). Cer with "very long" acyl… read more here.
Keywords: lipid membranes; stratum corneum; acyl chains; microstructure model ... See more keywords
State of the art in Stratum Corneum research: The biophysical properties of ceramides.
Sign Up to like & getrecommendations! Published in 2018 at "Chemistry and physics of lipids"
DOI: 10.1016/j.chemphyslip.2018.09.017
Abstract: This review is summarizing an important part of the state of the art in stratum corneum research. A complete overview on discoveries about the general biophysical and physicochemical properties of the known ceramide species' is… read more here.
Keywords: stratum corneum; corneum research; stratum; art stratum ... See more keywords
Effects of ozone on stratum corneum lipid integrity and assembly.
Sign Up to like & getrecommendations! Published in 2021 at "Chemistry and physics of lipids"
DOI: 10.1016/j.chemphyslip.2021.105121
Abstract: The stratum corneum (SC) acts as the main barrier of the skin against exogenous substances (e.g. air pollutants) and against the loss of endogenous substances such as water. The SC consists of keratin-rich dead cells… read more here.
Keywords: stratum corneum; ozone stratum; effects ozone; stratum ... See more keywords
Overcoming or circumventing the stratum corneum barrier for efficient transcutaneous immunization.
Sign Up to like & getrecommendations! Published in 2018 at "Drug discovery today"
DOI: 10.1016/j.drudis.2017.09.017
Abstract: Transcutaneous immunization (TCI) is a promising alternative to vaccine delivery via the subcutaneous and intramuscular routes because of the unique immunological characteristics of the skin. However, the stratum corneum (SC) prevents entry of most therapeutic… read more here.
Keywords: circumventing stratum; stratum corneum; transcutaneous immunization; overcoming circumventing ... See more keywords
Development of a novel human stratum corneum model, as a tool in the optimization of drug formulations.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2019.118571
Abstract: Transdermal delivery represents a very attractive administration route that provides various advantages over other methods of administration, including enhanced patient compliance via non-invasive, painless and simple application and reduced side effects. Thereby, the research on… read more here.
Keywords: drug; model; stratum corneum; development novel ... See more keywords
Extraction of natural moisturizing factor from the stratum corneum and its implication on skin molecular mobility.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of colloid and interface science"
DOI: 10.1016/j.jcis.2021.07.012
Abstract: The natural moisturizing factor (NMF) is a mixture of small water-soluble compounds present in the upper layer of the skin, stratum corneum (SC). Soaking of SC in water leads to extraction of the NMF molecules,… read more here.
Keywords: stratum corneum; mobility; natural moisturizing; molecular mobility ... See more keywords
Age related depth profiles of human Stratum Corneum barrier-related molecular parameters by confocal Raman microscopy in vivo
Sign Up to like & getrecommendations! Published in 2018 at "Mechanisms of Ageing and Development"
DOI: 10.1016/j.mad.2017.08.011
Abstract: In this study, stratum corneum (SC) depth profiles of hydrogen bound water molecule types, intercellular lipid (ICL) ordering, concentration of natural moisturizing factor (NMF) and keratin folding/unfolding properties are investigated in vivo for older (mean… read more here.
Keywords: stratum corneum; raman microscopy; microscopy; water ... See more keywords