A chromatogram-simplified Streptomyces albus host for heterologous production of natural products
Sign Up to like & getrecommendations! Published in 2019 at "Antonie Van Leeuwenhoek"
DOI: 10.1007/s10482-019-01360-x
Abstract: Cloning natural product biosynthetic gene clusters from cultured or uncultured sources and their subsequent expression by genetically tractable heterologous hosts is an essential strategy for the elucidation and characterisation of novel microbial natural products. The… read more here.
Keywords: streptomyces albus; natural products; chromatogram simplified; simplified streptomyces ... See more keywords
Identification of butenolide regulatory system controlling secondary metabolism in Streptomyces albus J1074
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DOI: 10.1038/s41598-017-10316-y
Abstract: A large majority of genome-encrypted chemical diversity in actinobacteria remains to be discovered, which is related to the low level of secondary metabolism genes expression. Here, we report the application of a reporter-guided screening strategy… read more here.
Keywords: albus j1074; system; streptomyces albus; metabolism ... See more keywords
Building Streptomyces albus as a chassis for synthesis of bacterial terpenoids
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DOI: 10.1039/d2sc06033g
Abstract: Terpenoids comprise the most chemically and structurally diverse family of natural products. In contrast to the huge numbers of terpenoids discovered from plants and fungi, only a relatively small number of terpenoids were reported from… read more here.
Keywords: streptomyces albus; terpene; albus chassis; building streptomyces ... See more keywords
De Novo Biosynthesis of Apigenin, Luteolin, and Eriodictyol in the Actinomycete Streptomyces albus and Production Improvement by Feeding and Spore Conditioning
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2017.00921
Abstract: Nutraceutical compounds as plant flavonoids play an important role in prevention and modulation of diverse heath conditions, as they exert interesting antifungal, antibacterial, antioxidant, and antitumor effects. They also possess anti-inflammatory activities in arthritis, cardiovascular… read more here.
Keywords: spore conditioning; streptomyces albus; apigenin luteolin; production ... See more keywords
Optimization of Pre-Inoculum, Fermentation Process Parameters and Precursor Supplementation Conditions to Enhance Apigenin Production by a Recombinant Streptomyces albus Strain
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DOI: 10.3390/fermentation7030161
Abstract: Streptomyces albus J1074-pAPI (Streptomyces albus-pAPI) is a recombinant strain constructed to biotechnologically produce apigenin, a flavonoid with interesting bioactive features that up to now has been manufactured by extraction from plants with long and not… read more here.
Keywords: streptomyces albus; apigenin production; fermentation; fermentation process ... See more keywords