Biochemical Characterization of GacI, a Bifunctional Glycosyltransferase-Phosphatase Enzyme Involved in Acarbose Biosynthesis in Streptomyces glaucescens GLA.O.
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DOI: 10.1021/acs.biochem.2c00473
Abstract: Acarbose, a pseudotetrasaccharide produced by several strains of Actinoplanes and Streptomyces, is an α-glucosidase inhibitor clinically used to control type II diabetes. Bioinformatic analysis of the biosynthetic gene clusters of acarbose in Actinoplanes sp. SE50/110… read more here.
Keywords: bifunctional glycosyltransferase; acarbose biosynthesis; streptomyces glaucescens; phosphatase enzyme ... See more keywords
Enantioselective sulfoxidation using Streptomyces glaucescens GLA.0
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DOI: 10.1039/d0ra05838f
Abstract: Asymmetric oxidation of prochiral sulfides is a direct means for production of enantiopure sulfoxides which are important in organic synthesis and the pharmaceutical industry. In the present study, Streptomyces glaucescens GLA.0 was employed for stereoselective… read more here.
Keywords: sulfoxidation using; enantioselective sulfoxidation; using streptomyces; glaucescens gla ... See more keywords