Global and pathway-specific transcriptional regulations of pactamycin biosynthesis in Streptomyces pactum
Sign Up to like & getrecommendations! Published in 2018 at "Applied Microbiology and Biotechnology"
DOI: 10.1007/s00253-018-9375-9
Abstract: Pactamycin, a structurally unique aminocyclitol natural product isolated from Streptomyces pactum, has potent antibacterial, antitumor, and anti-protozoa activities. However, its production yields under currently used culture conditions are generally low. To understand how pactamycin biosynthesis… read more here.
Keywords: production; pactamycin; pactamycin biosynthesis; streptomyces pactum ... See more keywords
Identification and Biological Activity of NFAT-133 Congeners from Streptomyces pactum.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of natural products"
DOI: 10.1021/acs.jnatprod.1c00152
Abstract: The soil bacterium Streptomyces pactum ATCC 27456 produces a number of polyketide natural products. Among them is NFAT-133, an inhibitor of the nuclear factor of activated T cells (NFAT) that suppresses interleukin-2 (IL-2) expression and… read more here.
Keywords: biological activity; atcc 27456; nfat 133; identification biological ... See more keywords
Modulation of Specialized Metabolite Production in Genetically Engineered Streptomyces pactum.
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DOI: 10.1021/acschembio.1c00718
Abstract: Filamentous soil bacteria are known to produce diverse specialized metabolites. Despite having enormous potential as a source of pharmaceuticals, they often produce bioactive metabolites at low titers. Here, we show that inactivation of the pactamycin,… read more here.
Keywords: production; conglobatin; modulation specialized; metabolite production ... See more keywords