Discovery of a Novel DNA Gyrase-Targeting Antibiotic through the Chemical Perturbation of Streptomyces venezuelae Sporulation
Sign Up to like & getrecommendations! Published in 2019 at "Cell Chemical Biology"
DOI: 10.1016/j.chembiol.2019.06.002
Abstract: Summary Common approaches to antibiotic discovery include small-molecule screens for growth inhibition in target pathogens and screens for inhibitors of purified enzymes. These approaches have a shared intent of seeking to directly target a vital… read more here.
Keywords: sporulation; discovery; streptomyces venezuelae; dna gyrase ... See more keywords
Spatial rearrangement of the Streptomyces venezuelae linear chromosome during sporogenic development
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-25461-2
Abstract: Bacteria of the genus Streptomyces have a linear chromosome, with a core region and two ‘arms’. During their complex life cycle, these bacteria develop multi-genomic hyphae that differentiate into chains of exospores that carry a… read more here.
Keywords: linear chromosome; rearrangement streptomyces; sporogenic; streptomyces venezuelae ... See more keywords
Targeted Metabolomics and High-Throughput RNA Sequencing-Based Transcriptomics Reveal Massive Changes in the Streptomyces venezuelae NRRL B-65442 Metabolism Caused by Ethanol Shock
Sign Up to like & getrecommendations! Published in 2022 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.03672-22
Abstract: Streptomyces spp. are filamentous Gram-positive bacteria known as versatile producers of secondary metabolites, of which some have been developed into human medicines against infections and cancer. The genomes of these bacteria harbor dozens of gene… read more here.
Keywords: venezuelae nrrl; biosynthesis; ethanol shock; streptomyces venezuelae ... See more keywords