Vitamin E improves testicular damage in streptozocin‐induced diabetic rats, via increasing vascular endothelial growth factor and poly(ADP‐ribose) polymerase‐1
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DOI: 10.1111/and.12925
Abstract: The precise mechanism by which diabetes impairs spermatogenesis and testicular function is not exactly known. Vascular endothelial growth factor (VEGF) and poly(ADP‐ribose) polymerase‐1 (PARP‐1) are important for germ cell homeostasis and repair of DNA respectively.… read more here.
Keywords: testicular damage; induced diabetic; parp; damage ... See more keywords
mTOR activation due to APPL1 deficiency exacerbates hyperalgesia via Rab5/Akt and AMPK signaling pathway in streptozocin-induced diabetic rats
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DOI: 10.1177/1744806919880643
Abstract: Painful diabetic neuropathy is a common complication of diabetes mellitus with obscure underlying mechanisms. The adaptor protein APPL1 is critical in mediating the insulin sensitizing and insulin signaling. In neurons, APPL1 reportedly affects synaptic plasticity,… read more here.
Keywords: painful diabetic; diabetic neuropathy; activation; neuropathy rats ... See more keywords