Protective effect of daidzein against streptozotocin‐induced Alzheimer's disease via improving cognitive dysfunction and oxidative stress in rat model
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.22319
Abstract: Oxidative stress is performing an essential role in developing Alzheimer's disease (AD), and age‐related disorder and other neurodegenerative diseases. In existing research, we have aimed at investigating the daidzein (4′,7‐dihydroxyisoflavone) effect (10 and 20 mg/kg of… read more here.
Keywords: daidzein; effect; streptozotocin; effect daidzein ... See more keywords
Effect of Standard and High-Fat Diets during Modeling of Streptozotocin-Induced Diabetes in Rats on the Development of Complications.
Sign Up to like & getrecommendations! Published in 2021 at "Bulletin of experimental biology and medicine"
DOI: 10.1007/s10517-021-05144-0
Abstract: For evaluation of the effect of high-fat diet on the development of diabetic complications, the rats were maintained on standard or high-fat diet. In 3 weeks, diabetes mellitus was modeled by single intraperitoneal injection of… read more here.
Keywords: fat diets; effect; standard high; high fat ... See more keywords
Toxic Effect of Streptozotocin on Cultured Mouse Hippocampal Neurons.
Sign Up to like & getrecommendations! Published in 2021 at "Bulletin of experimental biology and medicine"
DOI: 10.1007/s10517-021-05305-1
Abstract: In primary dissociated hippocampal cell cultures from 18-day-old mouse embryos, streptozotocin in concentrations of 2-5 mM produced a dose-dependent cytotoxic effect on day 3 in vitro, whereas on day 11 of culturing, the neurons were… read more here.
Keywords: hippocampal neurons; toxic effect; effect; streptozotocin ... See more keywords
The role of apoptosis and autophagy in the insulin-enhancing activity of oxovanadium(IV) bipyridine complex in streptozotocin-induced diabetic mice
Sign Up to like & getrecommendations! Published in 2020 at "BioMetals"
DOI: 10.1007/s10534-020-00237-1
Abstract: Metal-based therapies (e.g. Vanadium) possess an attractive proposition in medicinal treatment of diabetes mellitus. Defective insulin secretion can result from impaired β-cell function which is mediated by many process including apoptosis and autophagy. In this… read more here.
Keywords: insulin; gsh sod; insulin enhancing; apoptosis autophagy ... See more keywords
Optimization of intracerebroventricular streptozotocin dose for the induction of neuroinflammation and memory impairments in rats
Sign Up to like & getrecommendations! Published in 2020 at "Metabolic Brain Disease"
DOI: 10.1007/s11011-020-00588-1
Abstract: Intracerebroventricular (ICV) injection of streptozotocin (STZ) is a well established procedure to induce neuroinflammation leading to dementia in experimental animals. However, the optimal dose of STZ has not been determined. In the present study, rats… read more here.
Keywords: optimization intracerebroventricular; neuroinflammation; streptozotocin dose; intracerebroventricular streptozotocin ... See more keywords
Neuroprotective effects of melatonin on erectile dysfunction in streptozotocin-induced diabetic rats
Sign Up to like & getrecommendations! Published in 2018 at "International Urology and Nephrology"
DOI: 10.1007/s11255-018-1989-4
Abstract: PurposeTo explore the neuroprotective effects and its possible mechanisms of melatonin (MT) on erectile dysfunction in streptozotocin-induced diabetic rats.MethodsTwenty-eight Sprague–Dawley rats received intraperitoneal injection of streptozotocin and 8 weeks later, the determined diabetic rats randomly got… read more here.
Keywords: neuroprotective effects; melatonin erectile; erectile dysfunction; dysfunction streptozotocin ... See more keywords
Nanocurcumin improved glucose metabolism in streptozotocin-induced diabetic rats: a comparison study with Gliclazide
Sign Up to like & getrecommendations! Published in 2020 at "Environmental Science and Pollution Research"
DOI: 10.1007/s11356-020-08941-8
Abstract: In the present study, the biochemical effect of nanocurcumin (nanoCUR) compared with Gliclazide (GLZ) on the diabetic rats was studied. Forty male albino rats (Sprague Dawley) weighted 110 ± 20 g were used. Rats were randomly separated into… read more here.
Keywords: induced diabetic; nanocur glz; study; streptozotocin ... See more keywords
Mesenchymal Stem Cells Therapy Improved the Streptozotocin-Induced Behavioral and Hippocampal Impairment in Rats
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Neurobiology"
DOI: 10.1007/s12035-019-01729-z
Abstract: Sporadic Alzheimer’s disease (sAD) is the most prevalent neurodegenerative pathology with no effective therapy until date. This disease promotes hippocampal degeneration, which in turn affects multiple cognitive domains and daily life activities. In this study,… read more here.
Keywords: behavioral hippocampal; streptozotocin; therapy; stem cells ... See more keywords
Nerve growth factor receptor TrkA signaling in streptozotocin-induced type 1 diabetes rat brain.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.04.162
Abstract: Previous work from our lab demonstrated a new role of TrkA in the insulin signaling pathway. The kinase activity of TrkA is essential for its interaction with the insulin receptor (IR) and insulin receptor substrate-1… read more here.
Keywords: insulin; trka; streptozotocin; receptor ... See more keywords
trans-Anethole attenuated renal injury and reduced expressions of angiotensin II receptor (AT1R) and TGF-β in streptozotocin-induced diabetic rats.
Sign Up to like & getrecommendations! Published in 2021 at "Biochimie"
DOI: 10.1016/j.biochi.2021.03.011
Abstract: Fibrosis is a pathological process in diabetic nephropathy that causes renal failure and dysfunction. Given the known anti-diabetic effects of trans-Anethole (TA), we aimed to investigate its renoprotective and anti-fibrotic effect alone and in combination… read more here.
Keywords: at1r tgf; trans anethole; combination; tgf ... See more keywords
Isoquercetin ameliorates hyperglycemia and regulates key enzymes of glucose metabolism via insulin signaling pathway in streptozotocin‐induced diabetic rats
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2018.04.015
Abstract: &NA; Among the foremost common flavonoids within the human diet, quercetin glycosides possess neuroprotective, cardioprotective, anti‐oxidative, chemopreventive, and anti‐allergic properties. Isoquercetin is one such promising candidate with anti‐diabetic potential. However, complete studies of its molecular… read more here.
Keywords: insulin; isoquercetin ameliorates; signaling pathway; streptozotocin ... See more keywords