MicroRNA‐30d preserves pancreatic islet β‐cell function through negative regulation of the JNK signaling pathway via SOCS3 in mice with streptozotocin‐induced diabetes mellitus
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.26569
Abstract: The loss of pancreatic islet β‐cell function represents the classical feature in the pathogenesis of type 2 diabetes mellitus (T2DM). Previous evidence has highlighted the involvement of the activated JNK pathway in relation to islet… read more here.
Keywords: streptozotocin induced; jnk; islet; mir 30d ... See more keywords
Caffeine improves bladder function in streptozotocin‐induced diabetic rats
Sign Up to like & getrecommendations! Published in 2019 at "Neurourology and Urodynamics"
DOI: 10.1002/nau.23799
Abstract: To examine the protective effects of caffeine in rats with diabetes mellitus (DM) by using urodynamics. read more here.
Keywords: streptozotocin induced; caffeine improves; improves bladder; induced diabetic ... See more keywords
Nebivolol, a β-blocker abrogates streptozotocin-induced behavioral, biochemical, and neurophysiological deficit by attenuating oxidative-nitrosative stress: a possible target for the prevention of diabetic neuropathy
Sign Up to like & getrecommendations! Published in 2017 at "Naunyn-Schmiedeberg's Archives of Pharmacology"
DOI: 10.1007/s00210-017-1450-8
Abstract: Metabolic abnormalities including hyperglycemia, hyperlipidemia, and oxidative-nitrosative stress are involved in the progression of diabetic neuropathy. In the present study, we targeted oxidative-nitrosative stress using nebivolol, a β1-receptor antagonist with vasodilator and antioxidant property, to… read more here.
Keywords: streptozotocin induced; nebivolol; diabetic neuropathy; oxidative nitrosative ... See more keywords
Evidence of antidiabetic activity of Spirulina fusiformis against streptozotocin-induced diabetic Wistar albino rats
Sign Up to like & getrecommendations! Published in 2018 at "3 Biotech"
DOI: 10.1007/s13205-018-1156-8
Abstract: The aim of our study is to investigate the protective effect of Spirulina fusiformis against streptozotocin-induced diabetes in Wistar albino rats. Rats were divided into five groups: group I was normal control, group II was… read more here.
Keywords: diabetic rats; streptozotocin induced; group; spirulina fusiformis ... See more keywords
Inhibition of liver mitochondrial membrane permeability transition pore opening by quercetin and vitamin E in streptozotocin-induced diabetic rats.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.08.114
Abstract: Diabetes mellitus is a chronic metabolic disorder characterized by rise in blood glucose levels and generation of free radicals which could induce mitochondrial membrane permeability transition (MMPT) pore opening. This study examined the in vivo action… read more here.
Keywords: vitamin; streptozotocin induced; activity; quercetin vitamin ... See more keywords
Analysis of hepatic transcriptome modulation exerted by γ-conglutin from lupins in a streptozotocin-induced diabetes model.
Sign Up to like & getrecommendations! Published in 2020 at "Gene"
DOI: 10.1016/j.gene.2020.145036
Abstract: Lupinus albus γ-conglutin is proposed to positively affect glucose metabolism through inhibition of hepatic glucose production and insulin-mimetic activity; however, the action mechanism is not entirely known. Besides, most studies had focused on its effect… read more here.
Keywords: streptozotocin induced; transcriptome modulation; hepatic transcriptome; conglutin ... See more keywords
Nephroprotective effect of Combretum micranthum G. Don in nicotinamide-streptozotocin induced diabetic nephropathy in rats: In-vivo and In-silico experiments.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2020.113133
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Combretum micranthum G. Don (CM) is extensively used in traditional medicine throughout West Africa and commonly known as "long-life herbal tea" or "plant to heal". Further, traditional healers frequently use the title plant… read more here.
Keywords: streptozotocin induced; combretum micranthum; micranthum nicotinamide; combretum ... See more keywords
Lutein downregulates retinal vascular endothelial growth factor possibly via hypoxia inducible factor 1 alpha and X-box binding protein 1 expression in streptozotocin induced diabetic rats
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DOI: 10.1016/j.jff.2017.01.023
Abstract: Abstract Lutein, a retinal-specific carotenoid, was assessed for angioprotective efficacy via hypoxia inducible factor (HIF1α) and X-box binding protein 1 (XBP1) pathway in diabetic retina. Streptozotocin-induced diabetic rats were orally gavaged with or without lutein… read more here.
Keywords: streptozotocin induced; induced diabetic; via hypoxia; diabetic rats ... See more keywords
Cilostazol alleviates streptozotocin‐induced testicular injury in rats via PI3K/Akt pathway
Sign Up to like & getrecommendations! Published in 2018 at "Life Sciences"
DOI: 10.1016/j.lfs.2018.02.038
Abstract: Aims Male infertility prevalence is higher in diabetic patients. Those patients exhibit testicular oxidative damage due to sustained hyperglycemia and inflammation. The study has investigated the efficacy of cilostazol, a phosphodiesterase 3 inhibitor, on testicular… read more here.
Keywords: pi3k; streptozotocin induced; cilostazol alleviates; alleviates streptozotocin ... See more keywords
Streptozotocin induced hyperglycemia stimulates molecular signaling that promotes cell cycle reentry in mouse hippocampus
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DOI: 10.1016/j.lfs.2018.05.019
Abstract: Aims: Cerebral atrophy resulting from neurodegeneration is highly prevalent in individuals with diabetes; however, the underlying mechanisms for diabetic neurodegeneration are not fully understood. Here we hypothesized that hyperglycemia induces molecular signaling that favors induction… read more here.
Keywords: streptozotocin induced; hippocampus; molecular signaling; cell cycle ... See more keywords
Isoformononetin, a dietary isoflavone protects against streptozotocin induced rat model of neuroinflammation through inhibition of NLRP3/ASC/IL-1 axis activation.
Sign Up to like & getrecommendations! Published in 2021 at "Life sciences"
DOI: 10.1016/j.lfs.2021.119989
Abstract: AIMS Isoformononetin (IFN), a methoxyl isoflavone present in most of human dietary supplements. However, being a highly potent antioxidant and anti-inflammatory molecule, its activity against neuronal oxidative stress and neuroinflammation has not been explored till… read more here.
Keywords: nlrp3 asc; streptozotocin induced; asc; neuroinflammation ... See more keywords