Translation stress and collided ribosomes are co-activators of cGAS
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DOI: 10.1016/j.molcel.2021.05.018
Abstract: Summary The cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway senses cytosolic DNA and induces interferon-stimulated genes (ISGs) to activate the innate immune system. Here, we report the unexpected discovery that cGAS also senses dysfunctional… read more here.
Keywords: cgas; translation stress; stress collided; translation ... See more keywords