Nrf2 deficiency in mice attenuates erythropoietic stress-related macrophage hypercellularity.
Sign Up to like & getrecommendations! Published in 2020 at "Experimental hematology"
DOI: 10.1016/j.exphem.2020.02.005
Abstract: Erythropoiesis in the bone marrow and spleen depends upon intricate interactions between the resident macrophages and erythroblasts. Our study focuses on identifying the role of the Nuclear Factor Erythroid 2-related factor 2 (Nrf2) during recovery… read more here.
Keywords: stress erythropoiesis; stress; erythropoiesis; macrophage hypercellularity ... See more keywords
Neocytolysis: How to Get Rid of the Extra Erythrocytes Formed by Stress Erythropoiesis Upon Descent From High Altitude
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2018.00345
Abstract: Neocytolysis is the selective destruction of those erythrocytes that had been formed during stress-erythropoiesis in hypoxia in order to increase the oxygen transport capacity of blood. Neocytolysis likely aims at decreasing this excess amount of… read more here.
Keywords: erythrocytes formed; hemoglobin; stress erythropoiesis; high altitude ... See more keywords
Metabolic regulation of stress erythropoiesis, outstanding questions, and possible paradigms
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2022.1063294
Abstract: Steady state erythropoiesis produces new erythrocytes at a constant rate to replace the senescent cells that are removed by macrophages in the liver and spleen. However, infection and tissue damage disrupt the production of erythrocytes… read more here.
Keywords: metabolic regulation; erythropoiesis; differentiation; stress erythropoiesis ... See more keywords
Functional requirements for a Samd14-capping protein complex in stress erythropoiesis
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.7554/elife.76497
Abstract: Acute anemia induces rapid expansion of erythroid precursors and accelerated differentiation to replenish erythrocytes. Paracrine signals – involving cooperation between SCF/c-Kit signaling and other signaling inputs – are required for the increased erythroid precursor activity… read more here.
Keywords: protein complex; stress; kit signaling; capping protein ... See more keywords