TGFβ1 induces stress fiber formation through upregulation of TRPC6 in vascular smooth muscle cells.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2016.12.179
Abstract: Aberrant transforming growth factor β1 (TGFβ1) signaling plays a crucial role in the pathogenesis of vascular fibrosis. On the other hand, deregulated transient receptor potential canonical 6 (TRPC6) channel expression shows impaired vascular physiology and… read more here.
Keywords: stress fiber; vascular smooth; fiber formation; muscle cells ... See more keywords
Topography on a subcellular scale modulates cellular adhesions and actin stress fiber dynamics in tumor associated fibroblasts.
Sign Up to like & getrecommendations! Published in 2017 at "Physical biology"
DOI: 10.1088/1478-3975/aa7acc
Abstract: Cells can sense and adapt to mechanical properties of their environment. The local geometry of the extracellular matrix, such as its topography, has been shown to modulate cell morphology, migration, and proliferation. Here we investigate… read more here.
Keywords: topography; stress fiber; tumor associated; subcellular scale ... See more keywords
BAG6 supports stress fiber formation by preventing the ubiquitin-mediated degradation of RhoA
Sign Up to like & getrecommendations! Published in 2023 at "Molecular Biology of the Cell"
DOI: 10.1091/mbc.e22-08-0355
Abstract: The Rho family of small GTPases is a key regulator of cytoskeletal actin polymerization. Although the ubiquitination of Rho proteins is reported to control their activity, the mechanisms by which the ubiquitination of Rho family… read more here.
Keywords: fiber formation; stress fiber; rhoa; bag6 ... See more keywords
The Mechanical Contribution of Vimentin to Cellular Stress Generation.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of biomechanical engineering"
DOI: 10.1115/1.4039308
Abstract: Contractile stress generation by adherent cells is largely determined by the interplay of forces within their cytoskeleton. It is known that actin stress fibers, connected to focal adhesions, provide contractile stress generation, while microtubules and… read more here.
Keywords: vimentin; stress fiber; net stress; stress ... See more keywords
Lysophosphatidylinositol Induced Morphological Changes and Stress Fiber Formation through the GPR55-RhoA-ROCK Pathway
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms231810932
Abstract: We previously reported that lysophosphatidylinositol (LPI) functions as an endogenous agonist of GPR55, a novel cannabinoid receptor. However, the physiological roles of LPI-GPR55 have not yet been elucidated in detail. In the present study, we… read more here.
Keywords: morphological changes; rock; induced morphological; gpr55 ... See more keywords