Image-Based Screening for Stress Granule Regulators.
Sign Up to like & getrecommendations! Published in 2022 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1975-9_22
Abstract: Stress granule (SG)-based RNA interference (RNAi) screening is a powerful method to discover factors that control protein synthesis and aggregation, as well as regulators of SG assembly and disassembly. Here, we describe how to set… read more here.
Keywords: image based; stress; stress granule; based screening ... See more keywords
Differences between acute and chronic stress granules, and how these differences may impact function in human disease
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2018.10.009
Abstract: Stress granules are macromolecular aggregates of mRNA and proteins assembling in response to stresses that promote the repression of protein synthesis. Most of the work characterizing stress granules has been done under acute stress conditions… read more here.
Keywords: chronic stress; stress granules; stress granule; stress ... See more keywords
PARPs and PAR as novel pharmacological targets for the treatment of stress granule-associated disorders.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2019.05.019
Abstract: Among the post-translational modifications, ADP-ribosylation has been for long time the least integrated in the scheme of the structural protein modifications affecting physiological functions. In spite of the original findings on bacterial-dependent ADP-ribosylation catalysed by… read more here.
Keywords: novel pharmacological; targets treatment; stress; stress granule ... See more keywords
The p.S85C-mutation in MATR3 impairs stress granule formation in Matrin-3 myopathy
Sign Up to like & getrecommendations! Published in 2018 at "Experimental Neurology"
DOI: 10.1016/j.expneurol.2018.05.012
Abstract: ABSTRACT Matrin‐3‐related distal myopathy is characterized mainly by progressive distal weakness of the lower extremities. The mutation p.S85C in matrin‐3 (MATR3) has been identified as disease‐causing alteration, whereas the specific molecular mechanisms leading to the… read more here.
Keywords: granule; stress granule; granule formation; stress ... See more keywords
Distinct features of stress granule proteins predict localization in membraneless organelle.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2020.02.020
Abstract: Recently generated proteomic data provides unprecedented insight into stress granule composition and stands as fruitful ground for further analysis. Stress granules are stress-induced biological assemblies that are of keen interest due to being linked to… read more here.
Keywords: stress granule; membraneless; distinct features; granule proteins ... See more keywords
The impact of hyperglycaemia on PKM2-mediated NLRP3 inflammasome/stress granule signalling in macrophages and its correlation with plaque vulnerability: an in vivo and in vitro study.
Sign Up to like & getrecommendations! Published in 2020 at "Metabolism: clinical and experimental"
DOI: 10.1016/j.metabol.2020.154231
Abstract: BACKGROUND The mechanism of pyruvate kinase M2 (PKM2)-mediated inflammatory signalling in macrophages when plaques rupture and the impact of hyperglycaemia on the signalling are unclear. The present study aimed to explore the impact of hyperglycaemia… read more here.
Keywords: nlrp3 inflammasome; hyperglycaemia; stress granule; pkm2 mediated ... See more keywords
TIA1 Mutations in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Promote Phase Separation and Alter Stress Granule Dynamics
Sign Up to like & getrecommendations! Published in 2017 at "Neuron"
DOI: 10.1016/j.neuron.2017.07.025
Abstract: Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are age-related neurodegenerative disorders with shared genetic etiologies and overlapping clinical and pathological features. Here we studied a novel ALS/FTD family and identified the P362L mutation in… read more here.
Keywords: frontotemporal dementia; tia1; stress granule; tia1 mutations ... See more keywords
Stress granule homeostasis is modulated by TRIM21-mediated ubiquitination of G3BP1 and autophagy-dependent elimination of stress granules.
Sign Up to like & getrecommendations! Published in 2023 at "Autophagy"
DOI: 10.1080/15548627.2022.2164427
Abstract: Eukaryotic stress granules (SGs) are highly dynamic assemblies of untranslated mRNAs and proteins that form through liquid-liquid phase separation (LLPS) under cellular stress. SG formation and elimination process is a conserved cellular strategy to promote… read more here.
Keywords: elimination; stress; stress granule; homeostasis ... See more keywords
De novo variants in genes regulating stress granule assembly associate with neurodevelopmental disorders
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abo7112
Abstract: Stress granules (SGs) are cytoplasmic assemblies in response to a variety of stressors. We report a new neurodevelopmental disorder (NDD) with common features of language problems, intellectual disability, and behavioral issues caused by de novo… read more here.
Keywords: genes regulating; stress; stress granule; novo variants ... See more keywords
A bending rigidity parameter for stress granule condensates
Sign Up to like & getrecommendations! Published in 2023 at "Science Advances"
DOI: 10.1126/sciadv.adg0432
Abstract: Interfacial tension plays an important role in governing the dynamics of droplet coalescence and determining how condensates interact with and deform lipid membranes and biological filaments. We demonstrate that an interfacial tension-only model is inadequate… read more here.
Keywords: stress granules; rigidity parameter; stress; stress granule ... See more keywords
ER regulates stress granule fission
Sign Up to like & getrecommendations! Published in 2020 at "Science"
DOI: 10.1126/science.367.6477.522-n
Abstract: Cell Biology A hallmark of eukaryotic cells is the ability to compartmentalize essential reactions into membrane-bound and membraneless organelles. Membrane-bound organelles form networks through transport vesicles and interorganellar contact sites. The endoplasmic reticulum (ER) has… read more here.
Keywords: regulates stress; stress granule; membrane bound; fission ... See more keywords