mRNPs meet stress granules
Sign Up to like & getrecommendations! Published in 2017 at "FEBS Letters"
DOI: 10.1002/1873-3468.12765
Abstract: Stress granules are cytoplasmic structures that form in response to a variety of cellular stresses. They contain mRNAs and many proteins including numerous types of RNA‐binding proteins, and have been studied in connection to major… read more here.
Keywords: meet stress; stress; stress granules; mrnps meet ... See more keywords
Hypoxia‐Induced FUS–circTBC1D14 Stress Granules Promote Autophagy in TNBC
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Science"
DOI: 10.1002/advs.202204988
Abstract: Triple‐negative breast cancer (TNBC) is a highly aggressive subtype of breast cancer that is suggested to be associated with hypoxia. This study is the first to identify a novel circular RNA (circRNA), circTBC1D14, whose expression… read more here.
Keywords: stress granules; fus circtbc1d14; hypoxia; tnbc ... See more keywords
Evaluation of Cooling-Induced Liquid-Liquid Phase Separation of Ureido Polymers as a Cold-Shock Stress Granules Model.
Sign Up to like & getrecommendations! Published in 2021 at "Macromolecular bioscience"
DOI: 10.1002/mabi.202000345
Abstract: Many intracellular reactions occur in membrane-less organelles that form due to liquid-liquid phase separation (LLPS). Cold-shock stress granules, which are membrane-less organelles, are formed in response to a significant decrease in temperature and recruit biomolecules… read more here.
Keywords: stress granules; shock stress; liquid; ureido polymers ... See more keywords
Stress‐induced mRNP granules: Form and function of processing bodies and stress granules
Sign Up to like & getrecommendations! Published in 2019 at "Wiley Interdisciplinary Reviews: RNA"
DOI: 10.1002/wrna.1524
Abstract: In response to stress, cells must quickly reprogram gene expression to adapt and survive. This is achieved in part by altering levels of mRNAs and their translation into proteins. Recently, the formation of two stress‐induced… read more here.
Keywords: stress granules; processing bodies; induced mrnp; stress induced ... See more keywords
Detecting Stress Granules in Drosophila Neurons.
Sign Up to like & getrecommendations! Published in 2022 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1975-9_14
Abstract: Stress granules (SGs) are cytoplasmic ribonucleoprotein condensates that dynamically and reversibly assemble in response to stress. They are thought to contribute to the adaptive stress response by storing translationally inactive mRNAs as well as signaling… read more here.
Keywords: stress granules; stress; detecting stress; microscopy ... See more keywords
Evaluating Stress Granules in Pancreatic Cancer In Vitro and In Vivo.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8879-2_17
Abstract: Stress granules are nonmembranous organelles that function as a stress-adaptation mechanism. We have recently shown that stress granules are mobilized by mutant KRAS pancreatic cancer cells under stress to enhance tumor fitness and survival. In… read more here.
Keywords: stress granules; vitro vivo; granules pancreatic; pancreatic cancer ... See more keywords
Stress granules safeguard against MAPK signaling hyperactivation by sequestering PKC/Pck2: new findings and perspectives.
Sign Up to like & getrecommendations! Published in 2021 at "Current genetics"
DOI: 10.1007/s00294-021-01192-1
Abstract: Stress granule (SG) assembly is a conserved cellular strategy that copes with stress-related damage and promotes cell survival. SGs form through a process of liquid-liquid phase separation. Cellular signaling also appears to employ SG assembly… read more here.
Keywords: granules safeguard; stress granules; hyperactivation; mapk signaling ... See more keywords
Differences between acute and chronic stress granules, and how these differences may impact function in human disease
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2018.10.009
Abstract: Stress granules are macromolecular aggregates of mRNA and proteins assembling in response to stresses that promote the repression of protein synthesis. Most of the work characterizing stress granules has been done under acute stress conditions… read more here.
Keywords: chronic stress; stress granules; stress granule; stress ... See more keywords
The Nuclear SUMO-Targeted Ubiquitin Quality Control Network Regulates the Dynamics of Cytoplasmic Stress Granules.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular cell"
DOI: 10.1016/j.molcel.2020.05.017
Abstract: Exposure of cells to heat or oxidative stress causes misfolding of proteins. To avoid toxic protein aggregation, cells have evolved nuclear and cytosolic protein quality control (PQC) systems. In response to proteotoxic stress, cells also… read more here.
Keywords: stress granules; targeted ubiquitin; stress; sumo targeted ... See more keywords
Small-Molecule Modulation of TDP-43 Recruitment to Stress Granules Prevents Persistent TDP-43 Accumulation in ALS/FTD
Sign Up to like & getrecommendations! Published in 2019 at "Neuron"
DOI: 10.1016/j.neuron.2019.05.048
Abstract: Stress granules (SGs) form during cellular stress and are implicated in neurodegenerative diseases such as amyotrophic lateral sclerosis and frontotemporal dementia (ALS/FTD). To yield insights into the role of SGs in pathophysiology, we performed a… read more here.
Keywords: accumulation; stress granules; small molecule; recruitment ... See more keywords
SARS-CoV-2 nucleocapsid protein phase separates with G3BPs to disassemble stress granules and facilitate viral production
Sign Up to like & getrecommendations! Published in 2021 at "Science Bulletin"
DOI: 10.1016/j.scib.2021.01.013
Abstract: A key to tackling the coronavirus disease 2019 (COVID-19) pandemic is to understand how severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) manages to outsmart host antiviral defense mechanisms. Stress granules (SGs), which are assembled during… read more here.
Keywords: protein; phase; stress granules; viral production ... See more keywords