Oxidative stress–mediated photoactivation of carbazole inhibits human skin cell physiology
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.29360
Abstract: Prolonged exposure of the earth's surface to the sun's ultraviolet radiation may result in various skin diseases and cataract. Carbazole (CBZ), as a polycyclic‐aromatic hydrocarbon (PAH), is blended with a five‐member nitrogen‐containing ring. It is… read more here.
Keywords: skin; physiology; stress mediated; cbz ... See more keywords
Extracts of Bauhinia Championii Alleviate Acute Neuronal Injury After Ischemic Reperfusion by Improving Endoplasmic Reticulum Stress-Mediated Neuronal Apoptosis
Sign Up to like & getrecommendations! Published in 2022 at "Current Medical Science"
DOI: 10.1007/s11596-022-2525-4
Abstract: Cerebral ischemia/reperfusion (I/R) is a potential factor for lethal injury, and currently lacks effective remedies. Bauhinia championii extracts (BCEs) have been reported to exhibit anti-oxidative and anti-hypoxia properties. The current work aimed to study whether… read more here.
Keywords: injury; stress mediated; reperfusion; neuronal apoptosis ... See more keywords
Three novel piperidones exhibit tumor-selective cytotoxicity on leukemia cells via protein degradation and stress-mediated mechanisms
Sign Up to like & getrecommendations! Published in 2021 at "Pharmacological Reports"
DOI: 10.1007/s43440-021-00322-3
Abstract: Background Cancer is an ongoing worldwide health problem. Although chemotherapy remains the mainstay therapy for cancer, it is not always effective and has detrimental side effects. Here, we present piperidone compounds P3, P4, and P5… read more here.
Keywords: stress; mediated mechanisms; via protein; cells via ... See more keywords
Pinocembrin induces ER stress mediated apoptosis and suppresses autophagy in melanoma cells.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer letters"
DOI: 10.1016/j.canlet.2018.05.026
Abstract: Melanoma, one of the toughest tumors to treat, features high metastasis and high lethality. Pinocembrin is a natural flavanone with versatile biological and pharmacological activities. Here, we evaluated the anti-tumor effects of pinocembrin against melanoma… read more here.
Keywords: melanoma; apoptosis; autophagy melanoma; melanoma cells ... See more keywords
Daucosterol disturbs redox homeostasis and elicits oxidative-stress mediated apoptosis in A549 cells via targeting thioredoxin reductase by a p53 dependent mechanism.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2019.04.051
Abstract: Daucosterol (DS) is a plant phytosterol which is shown to induce oxidative stress mediated apoptosis in various cancer cell lines. However, the molecular mechanism underlying its cellular action has not been documented against Non- Small… read more here.
Keywords: a549 cells; stress mediated; p53; cell ... See more keywords
Oxidative stress mediated anti-leishmanial activity of endoperoxides represent a new therapeutic strategy in Leishmaniasis
Sign Up to like & getrecommendations! Published in 2018 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2018.04.537
Abstract: Endoperoxides kill malaria parasites via cleavage of their endoperoxide bridge by heme or iron, leading to generation of cytotoxic oxygen-centered radicals. In view of the impaired anti-oxidant defense and high iron content of Leishmania parasites,… read more here.
Keywords: therapeutic strategy; activity; stress mediated; mediated anti ... See more keywords
Bone marrow mesenchymal stem cells could reduce the toxic effects of hexavalent chromium on the liver by decreasing endoplasmic reticulum stress-mediated apoptosis via SIRT1/HIF-1α signaling pathway in rats.
Sign Up to like & getrecommendations! Published in 2019 at "Toxicology letters"
DOI: 10.1016/j.toxlet.2019.04.007
Abstract: This study focused on the effect of bone marrow mesenchymal stem cells (BMSCs) on the repair of rat liver injury induced by Cr (VI). Twenty-four Wistar rats were randomly divided into the control, model and… read more here.
Keywords: sirt1; hif; apoptosis; group ... See more keywords
Osmotic-Stress-Mediated Control of Membrane Permeability of Polymeric Microcapsules
Sign Up to like & getrecommendations! Published in 2018 at "Chemistry of Materials"
DOI: 10.1021/acs.chemmater.8b03230
Abstract: Microcapsules with regular pore size can provide size-selective permeation, which is promising for immunoisolation of cells, protection of enzymes or catalysts, and development of capsule-type sensors. However, conventional approaches have limited biocompatibility or poor dispersion… read more here.
Keywords: control membrane; osmotic stress; stress; mediated control ... See more keywords
Physical Membrane-Stress-Mediated Antimicrobial Properties of Cellulose Nanocrystals
Sign Up to like & getrecommendations! Published in 2021 at "ACS Sustainable Chemistry & Engineering"
DOI: 10.1021/acssuschemeng.0c08317
Abstract: Cellulose nanocrystals (CNCs) have emerged as a sustainable nanomaterial for several environmental applications, including the development of novel antimicrobial agents. Although previous studies h... read more here.
Keywords: membrane stress; antimicrobial properties; stress mediated; physical membrane ... See more keywords
Reduced intracellular chloride concentration impairs angiogenesis by inhibiting oxidative stress-mediated VEGFR2 activation
Sign Up to like & getrecommendations! Published in 2020 at "Acta Pharmacologica Sinica"
DOI: 10.1038/s41401-020-0458-7
Abstract: Chloride (Cl−) homeostasis is of great significance in cardiovascular system. Serum Cl− level is inversely associated with the mortality of patients with heart failure. Considering the importance of angiogenesis in the progress of heart failure,… read more here.
Keywords: mediated vegfr2; angiogenesis; reduced intracellular; activation ... See more keywords
A broadly applicable, stress-mediated bacterial death pathway regulated by the phosphotransferase system (PTS) and the cAMP-Crp cascade
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2118566119
Abstract: Significance Finding that pan-tolerance derives from defects in carbohydrate regulation connects stress-mediated lesions with metabolic change, identifies a stable type of tolerance, and demonstrates a widely shared death response. Manipulation of the response should improve… read more here.
Keywords: stress mediated; pan tolerance; death; tolerance ... See more keywords